Downstream signal transduction

Reviewed: Heldin, CH, 2008-11-23 19:29:34 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 The role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of around 100 amino acids that can bind a phosphorylated tyrosine residue. These downstream molecules are activated upon binding to, or phosphorylated by, the receptor kinases intrinsic to PDGF receptors.<br>Some of the dowstream molecules are themselves enzymes, such as phosphatidylinositol 3'-kinase (PI3K), phospholipase C (PLC-gamma), the Src family of tyrosine kinases, the tyrosine phosphatase SHP2, and a GTPase activating protein (GAP) for Ras. Others such as Grb2 are adaptor molecules which link the receptor with downstream catalytic molecules. Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27

http://purl.obolibrary.org/obo/HINO_0026646

Reviewed: Heldin, CH, 2008-11-23 19:29:34

Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27

The role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of around 100 amino acids that can bind a phosphorylated tyrosine residue. These downstream molecules are activated upon binding to, or phosphorylated by, the receptor kinases intrinsic to PDGF receptors.
Some of the dowstream molecules are themselves enzymes, such as phosphatidylinositol 3'-kinase (PI3K), phospholipase C (PLC-gamma), the Src family of tyrosine kinases, the tyrosine phosphatase SHP2, and a GTPase activating protein (GAP) for Ras. Others such as Grb2 are adaptor molecules which link the receptor with downstream catalytic molecules.

Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27

Pubmed10508235

Reactome, http://www.reactome.org

Pubmed9739761

Pubmed1374684

Downstream signal transduction

http://purl.obolibrary.org/obo/NCBITaxon_9606

HINO:0026646

Downstream signal transduction

ReactomeREACT_17025

Reactome Database ID Release 43186763

http://purl.obolibrary.org/obo/INO_0000021

http://purl.obolibrary.org/obo/HINO_0022856

http://purl.obolibrary.org/obo/HINO_0022858

http://purl.obolibrary.org/obo/HINO_0022898

http://purl.obolibrary.org/obo/HINO_0016078

http://purl.obolibrary.org/obo/HINO_0016072

http://purl.obolibrary.org/obo/HINO_0022873

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http://purl.obolibrary.org/obo/HINO_0015984

http://purl.obolibrary.org/obo/HINO_0022908

http://purl.obolibrary.org/obo/HINO_0022900

http://purl.obolibrary.org/obo/HINO_0022904

http://purl.obolibrary.org/obo/HINO_0022906

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http://purl.obolibrary.org/obo/HINO_0022860

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http://purl.obolibrary.org/obo/HINO_0022868

http://purl.obolibrary.org/obo/HINO_0022862

http://purl.obolibrary.org/obo/HINO_0022866