Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

PI3K catalyses the phosphorylation of PIP2 to PIP3

Synonyms
Definitions

Reviewed: Heldin, CH, 2008-11-23 19:29:34 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 PI3K's preferred substrate is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] which is phosphorylated to the trisphosphate [PI(3,4,5)P3]. PI3-kinase and its products have been found to be of importance in PDGF-stimulated actin reorganization, and directed cell movement, as well as in the stimulation of cell growth and inhibition of apoptosis. Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27

ID

http://purl.obolibrary.org/obo/HINO_0022900

comment

Reviewed: Heldin, CH, 2008-11-23 19:29:34

Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27

PI3K's preferred substrate is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] which is phosphorylated to the trisphosphate [PI(3,4,5)P3]. PI3-kinase and its products have been found to be of importance in PDGF-stimulated actin reorganization, and directed cell movement, as well as in the stimulation of cell growth and inhibition of apoptosis.

Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27

definition source

Pubmed2466336

Reactome, http://www.reactome.org

Pubmed9739761

has input

http://purl.obolibrary.org/obo/CHEBI_18348

http://purl.obolibrary.org/obo/CHEBI_15422

has output

http://purl.obolibrary.org/obo/CHEBI_16618

http://purl.obolibrary.org/obo/CHEBI_16761

label

PI3K catalyses the phosphorylation of PIP2 to PIP3

prefixIRI

HINO:0022900

prefLabel

PI3K catalyses the phosphorylation of PIP2 to PIP3

seeAlso

ReactomeREACT_16877

EC Number: 2.7.1.153

Reactome Database ID Release 43186800

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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