loading...| Preferred Name |
SH2 domain of Src binds to the active receptor |
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| Synonyms |
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| Definitions |
The Src family of tyrosine kinases are characterized by a SH3 and a SH2 domain in addition to the kinase domain.Src is activated when the SH2 domain binds to autophosphorylation sites on PDGF receptors (Tyr579 and 581 in the beta-receptor, Tyr572 and 574 in the alpha receptor), in conjuction with dephosporylation of the COOH-terminal phosphorylated tyrosine 527. Reviewed: Heldin, CH, 2008-11-23 19:29:34 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0022908 |
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| comment |
The Src family of tyrosine kinases are characterized by a SH3 and a SH2 domain in addition to the kinase domain.Src is activated when the SH2 domain binds to autophosphorylation sites on PDGF receptors (Tyr579 and 581 in the beta-receptor, Tyr572 and 574 in the alpha receptor), in conjuction with dephosporylation of the COOH-terminal phosphorylated tyrosine 527. Reviewed: Heldin, CH, 2008-11-23 19:29:34 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 |
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| definition source |
Pubmed10508235 Pubmed7685273 Pubmed9488729 Reactome, http://www.reactome.org Pubmed9739761 |
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| label |
SH2 domain of Src binds to the active receptor |
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| prefixIRI |
HINO:0022908 |
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| prefLabel |
SH2 domain of Src binds to the active receptor |
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| seeAlso |
Reactome Database ID Release 43186819 ReactomeREACT_17048 |
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