loading...| Preferred Name |
Nck binds to the active PDGF receptor |
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| Synonyms |
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| Definitions |
Nck is a widely expressed protein consisting exclusively of SH2 and SH3 domains. With its SH2 doamin Nck interacts with Tyr571 of the PDGF beta-receptor and it also interacts with the alpha-receptor, but the sites of interaction has not been determined. Nck is involved in the activation of the JNK serine/threonine kinase through interaction with the serine/threonine kinases PAK1 and NIK. Reviewed: Heldin, CH, 2008-11-23 19:29:34 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0022866 |
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| comment |
Nck is a widely expressed protein consisting exclusively of SH2 and SH3 domains. With its SH2 doamin Nck interacts with Tyr571 of the PDGF beta-receptor and it also interacts with the alpha-receptor, but the sites of interaction has not been determined. Nck is involved in the activation of the JNK serine/threonine kinase through interaction with the serine/threonine kinases PAK1 and NIK. Reviewed: Heldin, CH, 2008-11-23 19:29:34 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 |
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| definition source |
Pubmed10508235 Pubmed7692233 Reactome, http://www.reactome.org Pubmed9739761 |
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| label |
Nck binds to the active PDGF receptor |
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| prefixIRI |
HINO:0022866 |
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| prefLabel |
Nck binds to the active PDGF receptor |
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| seeAlso |
Reactome Database ID Release 43382058 ReactomeREACT_16997 |
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