Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Gene Expression

Synonyms
Definitions

Gene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are processed. Most annotation is centered on the generation of messenger RNAs (mRNAs) by regulated RNA polymerase II (PolII) transcription, although the activities of PolI and PolIII are also covered briefly, as are some aspects of microRNA generation and function.<p>Aspects of mRNA synthesis annotated here include the assembly of transcription factor complexes and their role in targeting specific genes for transcription, PolII-mediated transcription (RNA synthesis) itself, and the co- and post-translational processing of this RNA, via capping, splicing, and 3'-cleavage and polyadenylation to yield mature mRNA molecules that are exported from the nucleus. mRNA editing and nonsense-mediated decay are also annotated. Processes leading to mRNA breakdown are described: deadenylation-dependent mRNA decay, microRNA-mediated RNA cleavage, and regulation of mRNA stability by proteins that bind AU-rich elements.<p>Other pathways included here are tRNA aminoacylation and snRNP assembly. Authored: Kornblihtt, AR, Proudfoot, NJ, Caudy, M, D'Eustachio, P, 2008-12-03 01:43:15 Edited: Joshi-Tope, G, 0000-00-00 00:00:00

ID

http://purl.obolibrary.org/obo/HINO_0016637

comment

Gene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are processed. Most annotation is centered on the generation of messenger RNAs (mRNAs) by regulated RNA polymerase II (PolII) transcription, although the activities of PolI and PolIII are also covered briefly, as are some aspects of microRNA generation and function.

Aspects of mRNA synthesis annotated here include the assembly of transcription factor complexes and their role in targeting specific genes for transcription, PolII-mediated transcription (RNA synthesis) itself, and the co- and post-translational processing of this RNA, via capping, splicing, and 3'-cleavage and polyadenylation to yield mature mRNA molecules that are exported from the nucleus. mRNA editing and nonsense-mediated decay are also annotated. Processes leading to mRNA breakdown are described: deadenylation-dependent mRNA decay, microRNA-mediated RNA cleavage, and regulation of mRNA stability by proteins that bind AU-rich elements.

Other pathways included here are tRNA aminoacylation and snRNP assembly.

Authored: Kornblihtt, AR, Proudfoot, NJ, Caudy, M, D'Eustachio, P, 2008-12-03 01:43:15

Edited: Joshi-Tope, G, 0000-00-00 00:00:00

definition source

Reactome, http://www.reactome.org

label

Gene Expression

located_in

http://purl.obolibrary.org/obo/NCBITaxon_9606

prefixIRI

HINO:0016637

prefLabel

Gene Expression

seeAlso

ReactomeREACT_71

GENE ONTOLOGYGO:0010467

Reactome Database ID Release 4374160

subClassOf

http://purl.obolibrary.org/obo/INO_0000021

has_part

http://purl.obolibrary.org/obo/HINO_0016625

http://purl.obolibrary.org/obo/HINO_0016707

http://purl.obolibrary.org/obo/HINO_0016647

http://purl.obolibrary.org/obo/HINO_0016672

http://purl.obolibrary.org/obo/HINO_0016671

http://purl.obolibrary.org/obo/HINO_0016676

http://purl.obolibrary.org/obo/HINO_0016717

http://purl.obolibrary.org/obo/HINO_0016664

http://purl.obolibrary.org/obo/HINO_0015392

http://purl.obolibrary.org/obo/HINO_0016630

http://purl.obolibrary.org/obo/HINO_0016635

http://purl.obolibrary.org/obo/HINO_0021090

http://purl.obolibrary.org/obo/HINO_0021086

http://purl.obolibrary.org/obo/HINO_0021087

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http://purl.obolibrary.org/obo/GO_0010467 FYPO LOOM
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http://purl.obolibrary.org/obo/GO_0010467 RBO LOOM
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http://purl.obolibrary.org/obo/GO_0010467 CL LOOM
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http://doe-generated-ontology.com/OntoAD#C0017262 ONTOAD LOOM
http://bioontology.org/ontologies/BiomedicalResourceOntology.owl#Gene_Expression DINTO LOOM
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http://bioontology.org/ontologies/BiomedicalResourceOntology.owl#Gene_Expression BRO LOOM
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http://phenomebrowser.net/ontologies/mesh/mesh.owl#G05.355.310 RH-MESH LOOM
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http://www.semanticweb.org/osnathakimi/ontologies/deb#GeneExpression DEB LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Gene_Expression APAONTO LOOM
http://www.projecthalo.com/aura#Gene-Expression AURA LOOM
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http://purl.obolibrary.org/obo/GO_0010467 CLO LOOM
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http://purl.obolibrary.org/obo/GO_0010467 PSDO LOOM
http://purl.obolibrary.org/obo/GO_0010467 PLANP LOOM
http://purl.obolibrary.org/obo/GO_0010467 FOVT LOOM
http://purl.obolibrary.org/obo/GO_0010467 HOIP LOOM
http://purl.obolibrary.org/obo/GO_0010467 CHEAR LOOM
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http://purl.obolibrary.org/obo/GO_0010467 OBI_BCGO LOOM
http://purl.obolibrary.org/obo/GO_0010467 GEXO LOOM
http://purl.obolibrary.org/obo/GO_0010467 XPO LOOM
http://purl.obolibrary.org/obo/GO_0010467 EGO LOOM
http://purl.obolibrary.org/obo/GO_0010467 PHAGE LOOM
http://purl.obolibrary.org/obo/GO_0010467 CMPO LOOM
http://purl.obolibrary.org/obo/GO_0010467 GO-PLUS LOOM
http://purl.obolibrary.org/obo/GO_0010467 PCL LOOM
http://purl.obolibrary.org/obo/GO_0010467 PATO LOOM
http://purl.obolibrary.org/obo/GO_0010467 BAO LOOM
http://purl.obolibrary.org/obo/GO_0010467 BIPON LOOM
http://purl.obolibrary.org/obo/GO_0010467 NIFDYS LOOM
http://purl.obolibrary.org/obo/GO_0010467 BERO LOOM
http://purl.obolibrary.org/obo/GO_0010467 HHEAR LOOM
http://purl.obolibrary.org/obo/GO_0010467 TXPO LOOM
http://purl.obolibrary.org/obo/GO_0010467 STATO LOOM
http://purl.obolibrary.org/obo/GO_0010467 UPHENO LOOM
http://purl.obolibrary.org/obo/GO_0010467 OMP LOOM
http://purl.obolibrary.org/obo/GO_0010467 OBI_IEE LOOM
http://purl.obolibrary.org/obo/GO_0010467 FTC LOOM
http://purl.obolibrary.org/obo/GO_0010467 NIFSTD LOOM
http://purl.obolibrary.org/obo/GO_0010467 CHIRO LOOM
http://purl.obolibrary.org/obo/GO_0010467 KTAO LOOM
http://purl.obolibrary.org/obo/GO_0010467 PHIPO LOOM
http://purl.obolibrary.org/obo/GO_0010467 REGN_GO LOOM
http://purl.obolibrary.org/obo/GO_0010467 GO LOOM
http://purl.obolibrary.org/obo/GO_0010467 OHMI LOOM
http://purl.obolibrary.org/obo/GO_0010467 NCRO LOOM
http://purl.obolibrary.org/obo/GO_0010467 IXNO LOOM
http://purl.obolibrary.org/obo/GO_0010467 ZP LOOM
http://purl.obolibrary.org/obo/GO_0010467 AISM LOOM
http://purl.obolibrary.org/obo/GO_0010467 NMDCO LOOM
http://purl.obolibrary.org/obo/GO_0010467 OGSF LOOM
http://www.ifomis.org/acgt/1.0#GeneExpression ACGT-MO LOOM
http://www.semanticweb.org/bowenliu/ontologies/2020/4/untitled-ontology-8#gene_expression BIFO LOOM
http://purl.obolibrary.org/obo/IEV_0000182 PTS LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571345044435366039 ACVD_ONTOLOGY LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16608 NCIT LOOM
http://purl.obolibrary.org/obo/NCIT_C16608 PREMEDONTO LOOM
http://purl.obolibrary.org/obo/NCIT_C16608 BERO LOOM
http://regenbase.org/ontology#RB_0008042 RB LOOM
http://www.phoc.org.cn/pmo/class/PMO_00062663 PMAPP-PMO LOOM
http://www.cvrgrid.org/files/ECGOntologyv1.owl#ECG_000000237 ECG LOOM
http://purl.bioontology.org/ontology/MESH/D015870 MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#5407 OCHV LOOM
http://jermontology.org/ontology/JERMOntology#Gene_expression JERM LOOM
http://www.cea.fr/ontotoxnuc#ExpressionGenique ONTOTOXNUC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0017262 OCHV LOOM
http://www.bootstrep.eu/ontology/GRO#GeneExpression GRO LOOM
http://purl.bioontology.org/net/brunel/panda#GeneExpression PANDA LOOM
http://purl.jp/bio/4/id/200906029178316375 IOBC LOOM
http://id.nlm.nih.gov/mesh/D015870 MDM LOOM
http://purl.obolibrary.org/obo/INO_0000102 INO LOOM
http://purl.obolibrary.org/obo/INO_0000102 DIDEO LOOM
http://purl.bioontology.org/ontology/CSP/1256-8024 CRISP LOOM
http://purl.obolibrary.org/obo/OMIT_0016499 OMIT LOOM
http://purl.bioontology.org/ontology/SNMI/F-E1310 SNMI LOOM
http://edamontology.org/topic_0203 BERO LOOM
http://edamontology.org/topic_0203 EDAM LOOM
http://edamontology.org/topic_0203 ITO LOOM
http://edamontology.org/topic_0203 BMT LOOM