Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Reviewed: Gagneux, P, 2010-04-16 N-linked glycosylation commences with the 14-step synthesis of a dolichol lipid-linked oligosaccharide (LLO) consisting of 14 sugars (2 core GlcNAcs, 9 mannoses and 3 terminal GlcNAcs). This pathway is highly conserved in eukaryotes, and a closely related pathway is found in many eubacteria and Archaea. Mutations in the genes associated with N-glycan precursor synthesis lead to a diverse group of disorders collectively known as Congenital Disorders of Glycosylation (type I and II) (Sparks et al, 1993). The phenotypes of these disorders reflect the important role that N-glycosylation has during development, controlling the folding and the properties of proteins in the secretory pathway, and proteins that mediate cell-to-cell interactions or timing of development. Edited: Jassal, B, 2009-11-10 Authored: Dall'Olio, GM, 2009-11-10

http://purl.obolibrary.org/obo/HINO_0016735

Reviewed: Gagneux, P, 2010-04-16

N-linked glycosylation commences with the 14-step synthesis of a dolichol lipid-linked oligosaccharide (LLO) consisting of 14 sugars (2 core GlcNAcs, 9 mannoses and 3 terminal GlcNAcs). This pathway is highly conserved in eukaryotes, and a closely related pathway is found in many eubacteria and Archaea. Mutations in the genes associated with N-glycan precursor synthesis lead to a diverse group of disorders collectively known as Congenital Disorders of Glycosylation (type I and II) (Sparks et al, 1993). The phenotypes of these disorders reflect the important role that N-glycosylation has during development, controlling the folding and the properties of proteins in the secretory pathway, and proteins that mediate cell-to-cell interactions or timing of development.

Edited: Jassal, B, 2009-11-10

Authored: Dall'Olio, GM, 2009-11-10

Reactome, http://www.reactome.org

Pubmed20301507

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

http://purl.obolibrary.org/obo/NCBITaxon_9606

HINO:0016735

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

ReactomeREACT_22433

GENE ONTOLOGYGO:0006488

Reactome Database ID Release 43446193

http://purl.obolibrary.org/obo/INO_0000021

http://purl.obolibrary.org/obo/HINO_0016734

http://purl.obolibrary.org/obo/HINO_0025392

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http://purl.obolibrary.org/obo/HINO_0025963

http://purl.obolibrary.org/obo/HINO_0025962

http://purl.obolibrary.org/obo/HINO_0025967

http://purl.obolibrary.org/obo/HINO_0025964

http://purl.obolibrary.org/obo/HINO_0025387

http://purl.obolibrary.org/obo/HINO_0025948

http://purl.obolibrary.org/obo/HINO_0025959

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