loading...| Preferred Name |
Flipping of the N-glycan precursor to inside the ER |
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| Definitions |
The precursor of the N-glycan sugar, now in the form of (GlcNAc)2 (Man)5 (PP-Dol), is flipped across the ER membrane, moving it from the cytosolic side into the ER lumen. The exact mechanism of this translocation is not well understood: the protein RFT1 is known to be involved (Helenius et al, 2002), along with an unknown flippase, which is distinct from the one that flips the Dol-P linked precursors (Dol-P-Mannose and Dol-P-glucose) (Sanyal et al, 2008). Defects in RFT1 are associated with Congenital Disorder of Glycosylation 1N (CDG1N) (Haeuptle MA et al, 2008). Reviewed: Gagneux, P, 2010-04-16 Edited: Jassal, B, 2009-11-10 Authored: Dall'Olio, GM, 2009-11-10 |
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http://purl.obolibrary.org/obo/HINO_0025961 |
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| comment |
The precursor of the N-glycan sugar, now in the form of (GlcNAc)2 (Man)5 (PP-Dol), is flipped across the ER membrane, moving it from the cytosolic side into the ER lumen. The exact mechanism of this translocation is not well understood: the protein RFT1 is known to be involved (Helenius et al, 2002), along with an unknown flippase, which is distinct from the one that flips the Dol-P linked precursors (Dol-P-Mannose and Dol-P-glucose) (Sanyal et al, 2008). Defects in RFT1 are associated with Congenital Disorder of Glycosylation 1N (CDG1N) (Haeuptle MA et al, 2008). Reviewed: Gagneux, P, 2010-04-16 Edited: Jassal, B, 2009-11-10 Authored: Dall'Olio, GM, 2009-11-10 |
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| definition source |
Pubmed11807558 Reactome, http://www.reactome.org Pubmed18313027 Pubmed18597486 |
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| label |
Flipping of the N-glycan precursor to inside the ER |
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| prefixIRI |
HINO:0025961 |
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| prefLabel |
Flipping of the N-glycan precursor to inside the ER |
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| seeAlso |
ReactomeREACT_22262 Reactome Database ID Release 43446212 |
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