loading...| Preferred Name |
Addition of the sixth mannose to the N-glycan precursor by ALG3. |
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| Definitions |
Reviewed: Gagneux, P, 2010-04-16 Edited: Jassal, B, 2009-11-10 Authored: Dall'Olio, GM, 2009-11-10 The sixth mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen and uses a different mannose donor (dolichyl phosphate D-mannose) than the previous steps. It has been proposed that ALG3, along with all the mannosyl- and glucosyl transferases in the N-glycan biosynthesis pathway that use dolichyl phosphate D-mannose or dolichyl phosphate D-glucose as donor, derive from duplications of a common ancestral enzyme (Oriol R et al, 2002). Defects in ALG3 are associated with Congenital Disorder of Glycosylation 1D (CDG1D) (Sun L et al, 2005). |
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http://purl.obolibrary.org/obo/HINO_0025962 |
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| comment |
Reviewed: Gagneux, P, 2010-04-16 Edited: Jassal, B, 2009-11-10 Authored: Dall'Olio, GM, 2009-11-10 The sixth mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen and uses a different mannose donor (dolichyl phosphate D-mannose) than the previous steps. It has been proposed that ALG3, along with all the mannosyl- and glucosyl transferases in the N-glycan biosynthesis pathway that use dolichyl phosphate D-mannose or dolichyl phosphate D-glucose as donor, derive from duplications of a common ancestral enzyme (Oriol R et al, 2002). Defects in ALG3 are associated with Congenital Disorder of Glycosylation 1D (CDG1D) (Sun L et al, 2005). |
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| definition source |
Pubmed15840742 Reactome, http://www.reactome.org Pubmed12200473 |
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| label |
Addition of the sixth mannose to the N-glycan precursor by ALG3. |
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| prefixIRI |
HINO:0025962 |
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| prefLabel |
Addition of the sixth mannose to the N-glycan precursor by ALG3. |
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| seeAlso |
ReactomeREACT_22415 Reactome Database ID Release 43446188 |
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