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Addition of a second mannose to the N-glycan precursor by ALG2 |
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| Definitions |
Reviewed: Gagneux, P, 2010-04-16 A second mannose is added to the N-glycan precursor via an alpha-1,3 linkage. The reaction is catalyzed by the mannosyltransferase ALG2. This is a bifunctional enzyme with both alpha 1,3- and alpha 1,6-mannosyltransferase activities. In humans, only the alpha 1,3 activity used in this reaction has been elucidated (Thiel C et al, 2003). Defects in ALG2 are the cause of CDG1I (Thiel C et al, 2003). Edited: Jassal, B, 2009-11-10 Authored: Dall'Olio, GM, 2009-11-10 |
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http://purl.obolibrary.org/obo/HINO_0025966 |
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| comment |
Reviewed: Gagneux, P, 2010-04-16 A second mannose is added to the N-glycan precursor via an alpha-1,3 linkage. The reaction is catalyzed by the mannosyltransferase ALG2. This is a bifunctional enzyme with both alpha 1,3- and alpha 1,6-mannosyltransferase activities. In humans, only the alpha 1,3 activity used in this reaction has been elucidated (Thiel C et al, 2003). Defects in ALG2 are the cause of CDG1I (Thiel C et al, 2003). Edited: Jassal, B, 2009-11-10 Authored: Dall'Olio, GM, 2009-11-10 |
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| definition source |
Pubmed12684507 Reactome, http://www.reactome.org |
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Addition of a second mannose to the N-glycan precursor by ALG2 |
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| prefixIRI |
HINO:0025966 |
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| prefLabel |
Addition of a second mannose to the N-glycan precursor by ALG2 |
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| seeAlso |
Reactome Database ID Release 43446208 ReactomeREACT_22347 |
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