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Addition of N-acetyl-D-glucosamine to Dolichyl phosphate |
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| Definitions |
Reviewed: Gagneux, P, 2010-04-16 In the first step of N-glycan precursor (LLO) synthesis, N-acetylglucosamine is added, via an alpha-1,3 linkage, to a molecule of dolichyl phosphate, producing N-acetyl-D-glucosaminyl-diphosphodolichol (Eckert V et al, 1998). This reaction is catalyzed by DPAGT1 (ALG7 in yeast), mutations in which are associated with CDG disorder type I-J (Wu X et al, 2003). The dolichyl phosphate acts as an anchor for the LLO, so the following sugar-addition reactions take place on a sugar anchored in the ER membrane. Edited: Jassal, B, 2009-11-10 Authored: Dall'Olio, GM, 2009-11-10 |
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http://purl.obolibrary.org/obo/HINO_0025950 |
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| comment |
Reviewed: Gagneux, P, 2010-04-16 In the first step of N-glycan precursor (LLO) synthesis, N-acetylglucosamine is added, via an alpha-1,3 linkage, to a molecule of dolichyl phosphate, producing N-acetyl-D-glucosaminyl-diphosphodolichol (Eckert V et al, 1998). This reaction is catalyzed by DPAGT1 (ALG7 in yeast), mutations in which are associated with CDG disorder type I-J (Wu X et al, 2003). The dolichyl phosphate acts as an anchor for the LLO, so the following sugar-addition reactions take place on a sugar anchored in the ER membrane. Edited: Jassal, B, 2009-11-10 Authored: Dall'Olio, GM, 2009-11-10 |
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| definition source |
Reactome, http://www.reactome.org Pubmed9451016 Pubmed12872255 |
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Addition of N-acetyl-D-glucosamine to Dolichyl phosphate |
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HINO:0025950 |
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Addition of N-acetyl-D-glucosamine to Dolichyl phosphate |
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| seeAlso |
ReactomeREACT_22147 Reactome Database ID Release 43446191 EC Number: 2.7.8.15 |
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