loading...| Preferred Name |
Addition of the last mannose to the N-glycan precursor by ALG3, inside the ER lumen. |
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| Definitions |
Reviewed: Gagneux, P, 2010-04-16 Edited: Jassal, B, 2009-11-10 Authored: Dall'Olio, GM, 2009-11-10 The last mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen, uses Dolichyl phosphate D-mannose as the mannose donor, and is catalyzed by ALG9. Defects in ALG9 are the cause of congenital disorder of glycosylation type 1L (CDG1L) (Frank CG et al, 2004; Weinstein M et al, 2005). For many years ALG9 was thought to be involved in bipolar affective disorder (Baysal BE et al, 2002), but this hypothesis has been proven wrong (Baysal BE et al, 2006). |
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| ID |
http://purl.obolibrary.org/obo/HINO_0025960 |
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| comment |
Reviewed: Gagneux, P, 2010-04-16 Edited: Jassal, B, 2009-11-10 Authored: Dall'Olio, GM, 2009-11-10 The last mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen, uses Dolichyl phosphate D-mannose as the mannose donor, and is catalyzed by ALG9. Defects in ALG9 are the cause of congenital disorder of glycosylation type 1L (CDG1L) (Frank CG et al, 2004; Weinstein M et al, 2005). For many years ALG9 was thought to be involved in bipolar affective disorder (Baysal BE et al, 2002), but this hypothesis has been proven wrong (Baysal BE et al, 2006). |
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| definition source |
Pubmed15945070 Reactome, http://www.reactome.org Pubmed16859551 Pubmed15148656 Pubmed12030331 |
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Addition of the last mannose to the N-glycan precursor by ALG3, inside the ER lumen. |
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| prefixIRI |
HINO:0025960 |
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| prefLabel |
Addition of the last mannose to the N-glycan precursor by ALG3, inside the ER lumen. |
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| seeAlso |
Reactome Database ID Release 43446216 ReactomeREACT_22307 |
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