loading...| Preferred Name | liver | |
| Synonyms |
iecur jecur |
|
| Definitions |
An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. |
|
| ID |
http://purl.obolibrary.org/obo/UBERON_0002107 |
|
| axiom_lost_from_external_ontology |
relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO] |
|
| contributes to morphology of | ||
| database_cross_reference |
TAO:0000123 MAT:0000097 ZFA:0000123 UMLS:C0023884 NCIT:C12392 galen:Liver EHDAA2:0000997 MIAA:0000097 Wikipedia:Liver MESH:D008099 EFO:0000887 XAO:0000133 AAO:0010111 VHOG:0000257 EMAPA:16846 BTO:0000759 CALOHA:TS-0564 SCTID:181268008 EHDAA:2197 EV:0100089 FMA:7197 GAID:288 MA:0000358 |
|
| definition |
An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. |
|
| depiction |
https://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg https://cdn.humanatlas.io/digital-objects/ref-organ/liver-male/v1.2/assets/3d-vh-m-liver.glb https://cdn.humanatlas.io/digital-objects/ref-organ/liver-female/v1.2/assets/3d-vh-f-liver.glb |
|
| develops_from |
http://purl.obolibrary.org/obo/UBERON_0008836 |
|
| external_definition |
Organ which secretes bile and participates in formation of certain blood proteins.[AAO] |
|
| external_ontology_notes |
Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function. |
|
| function_notes |
secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. |
|
| has part | ||
| has_obo_namespace |
uberon |
|
| has_related_synonym |
iecur jecur |
|
| has_relational_adjective |
hepatic |
|
| homology_notes |
All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG] |
|
| id |
UBERON:0002107 |
|
| in taxon | ||
| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas http://purl.obolibrary.org/obo/uberon/core#efo_slim http://purl.obolibrary.org/obo/uberon/core#organ_slim http://purl.obolibrary.org/obo/uberon/core#vertebrate_core http://purl.obolibrary.org/obo/uberon/core#major_organ |
|
| label |
liver |
|
| notation |
UBERON:0002107 |
|
| overlaps |
http://purl.obolibrary.org/obo/UBERON_0002405 |
|
| part_of |
http://purl.obolibrary.org/obo/UBERON_0002423 http://purl.obolibrary.org/obo/UBERON_0000949 http://purl.obolibrary.org/obo/UBERON_0001007 |
|
| prefLabel |
liver |
|
| present_in_taxon | ||
| produces | ||
| site_of |
http://purl.obolibrary.org/obo/GO_0002384 |
|
| taxon_notes |
An organ sometimes referred to as a liver is found associated with the digestive tract of the primitive chordate Amphioxus. However, this is an enzyme secreting gland, not a metabolic organ, and it is unclear how truly homologous it is to the vertebrate liver. The zebrafish liver differs from the mammalian liver in that the hepatocytes are not clearly organized in cords or lobules and the typical portal triads are not apparent. In addition, the zebrafish liver does not have Kuppfer cells. Furthermore, a clear distinction can be made between the male and female liver in the adult zebrafish. The female hepatocytes are very basophilic (Figure 15c) as a result of the production of vitellogenin (Van der Ven et al. 2003). The liver is found in all vertebrates, and is typically the largest visceral organ. Its form varies considerably in different species, and is largely determined by the shape and arrangement of the surrounding organs. Nonetheless, in most species it is divided into right and left lobes; exceptions to this general rule include snakes, where the shape of the body necessitates a simple cigar-like form. The internal structure of the liver is broadly similar in all vertebrates. |
|
| treeView |
http://purl.obolibrary.org/obo/UBERON_0008836 http://purl.obolibrary.org/obo/UBERON_0003894 http://purl.obolibrary.org/obo/UBERON_0002423 http://purl.obolibrary.org/obo/UBERON_0000949 http://purl.obolibrary.org/obo/UBERON_0004161 http://purl.obolibrary.org/obo/UBERON_0001007 |
|
| disjointWith | ||
| subClassOf |
http://purl.obolibrary.org/obo/UBERON_0006925 http://purl.obolibrary.org/obo/UBERON_0004119 |