loading...| Preferred Name | GAB1 signalosome | |
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| Definitions |
Reviewed: Heldin, CH, 2008-02-12 09:44:02 Authored: Castagnoli, L, 2006-10-10 13:09:34 GAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also known as PI3Kp85), which subsequently recruits PIK3 catalytic subunit PIK3CA (also known as PI3Kp110). PIK3, in complex with EGFR, GRB2 and GAB1, catalyzes phosphorylation of PIP2 and its conversion to PIP3, which leads to the activation of the AKT signaling. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016079 |
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| comment |
Reviewed: Heldin, CH, 2008-02-12 09:44:02 Authored: Castagnoli, L, 2006-10-10 13:09:34 GAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also known as PI3Kp85), which subsequently recruits PIK3 catalytic subunit PIK3CA (also known as PI3Kp110). PIK3, in complex with EGFR, GRB2 and GAB1, catalyzes phosphorylation of PIP2 and its conversion to PIP3, which leads to the activation of the AKT signaling. |
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| definition source |
Reactome, http://www.reactome.org Pubmed15550174 |
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| label |
GAB1 signalosome |
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| located_in | ||
| prefixIRI |
HINO:0016079 |
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| prefLabel |
GAB1 signalosome |
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| seeAlso |
ReactomeREACT_12578 Reactome Database ID Release 43180292 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0009540 http://purl.obolibrary.org/obo/HINO_0009514 http://purl.obolibrary.org/obo/HINO_0009511 http://purl.obolibrary.org/obo/HINO_0009512 http://purl.obolibrary.org/obo/HINO_0009510 http://purl.obolibrary.org/obo/HINO_0016078 http://purl.obolibrary.org/obo/HINO_0009537 http://purl.obolibrary.org/obo/HINO_0009539 http://purl.obolibrary.org/obo/HINO_0009536 http://purl.obolibrary.org/obo/HINO_0009535 http://purl.obolibrary.org/obo/HINO_0009506 http://purl.obolibrary.org/obo/HINO_0009508 |