Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Binding of PIK3 regulatory alpha subunit to GRB2:GAB1
Synonyms
Definitions

Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 The Src homology 2 (SH2) domain of the phosphatidylinositol 3-kinase (PIK3) regulatory subunit (PIK3R1, i.e. PI3Kp85) binds to GAB1 in a phosphorylation-independent manner. GAB1 serves as a docking protein which recruits a number of downstream signalling proteins. PIK3R1 can bind to either GAB1 or phosphorylated GAB1. Authored: Castagnoli, L, 2006-10-10 13:09:34

ID

http://purl.obolibrary.org/obo/HINO_0009539

comment

Edited: Orlic-Milacic, Marija, 2011-08-25

Reviewed: Heldin, CH, 2008-02-12 09:44:02

The Src homology 2 (SH2) domain of the phosphatidylinositol 3-kinase (PIK3) regulatory subunit (PIK3R1, i.e. PI3Kp85) binds to GAB1 in a phosphorylation-independent manner. GAB1 serves as a docking protein which recruits a number of downstream signalling proteins. PIK3R1 can bind to either GAB1 or phosphorylated GAB1.

Authored: Castagnoli, L, 2006-10-10 13:09:34

definition source

Reactome, http://www.reactome.org

Pubmed11606067

has input

http://purl.obolibrary.org/obo/UniProt_P27986

http://purl.obolibrary.org/obo/HINO_0011909

has output

http://purl.obolibrary.org/obo/HINO_0011910

label

Binding of PIK3 regulatory alpha subunit to GRB2:GAB1

prefixIRI

HINO:0009539

prefLabel

Binding of PIK3 regulatory alpha subunit to GRB2:GAB1

seeAlso

ReactomeREACT_12616

Reactome Database ID Release 43177931

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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