loading...| Preferred Name | SHP2 dephosphorylates Tyr 992 on EGFR | |
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| Definitions |
Reviewed: Heldin, CH, 2008-02-12 09:44:02 The tyrosine-protein phosphatase SHP2 is a positive effector of EGFR signalling. SHP2 inhibits the tyrosine-dependent translocation of RasGAP (catalyses Ras inactivation) to the plasma membrane, thereby keeping it away from Ras-GTP (its substrate). This inhibition is achieved by the dephosphorylation of a RasGAP binding site on the EGF receptor. Authored: Castagnoli, L, 2006-10-10 13:09:34 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0009510 |
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| comment |
Reviewed: Heldin, CH, 2008-02-12 09:44:02 The tyrosine-protein phosphatase SHP2 is a positive effector of EGFR signalling. SHP2 inhibits the tyrosine-dependent translocation of RasGAP (catalyses Ras inactivation) to the plasma membrane, thereby keeping it away from Ras-GTP (its substrate). This inhibition is achieved by the dephosphorylation of a RasGAP binding site on the EGF receptor. Authored: Castagnoli, L, 2006-10-10 13:09:34 |
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| definition source |
Reactome, http://www.reactome.org Pubmed14560030 |
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SHP2 dephosphorylates Tyr 992 on EGFR |
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| prefixIRI |
HINO:0009510 |
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| prefLabel |
SHP2 dephosphorylates Tyr 992 on EGFR |
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| seeAlso |
Reactome Database ID Release 43177935 ReactomeREACT_12629 |
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