Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

GRB2:GAB1:PIK3R1 binds to phosphorylated EGFR
Synonyms
Definitions

Edited: Orlic-Milacic, Marija, 2011-08-25 Reviewed: Heldin, CH, 2008-02-12 09:44:02 The regulatory subunit of PIK3 mediates the association of GAB1 and receptor protein-tyrosine kinases such as the EGF receptor, which can phosphorylate GAB1. It appears that the PIK3 regulatory subunit acts as an adaptor protein allowing GAB1 to serve as a substrate for several tyrosine kinases. Authored: Castagnoli, L, 2006-10-10 13:09:34

ID

http://purl.obolibrary.org/obo/HINO_0009537

comment

Edited: Orlic-Milacic, Marija, 2011-08-25

Reviewed: Heldin, CH, 2008-02-12 09:44:02

The regulatory subunit of PIK3 mediates the association of GAB1 and receptor protein-tyrosine kinases such as the EGF receptor, which can phosphorylate GAB1. It appears that the PIK3 regulatory subunit acts as an adaptor protein allowing GAB1 to serve as a substrate for several tyrosine kinases.

Authored: Castagnoli, L, 2006-10-10 13:09:34

definition source

Pubmed9356464

Reactome, http://www.reactome.org

has input

http://purl.obolibrary.org/obo/HINO_0011981

http://purl.obolibrary.org/obo/HINO_0011910

has output

http://purl.obolibrary.org/obo/HINO_0011908

label

GRB2:GAB1:PIK3R1 binds to phosphorylated EGFR

prefixIRI

HINO:0009537

prefLabel

GRB2:GAB1:PIK3R1 binds to phosphorylated EGFR

seeAlso

Reactome Database ID Release 43177941

ReactomeREACT_12425

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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