loading...| Preferred Name |
Cimetidine |
|
| Synonyms |
|
|
| Definitions |
A histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine's ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C374 |
|
| Accepted_Therapeutic_Use_For |
Gastrointestinal conditions; allergic reaction prevention; immune modulation |
|
| ALT_DEFINITION |
A drug usually used to treat stomach ulcers and heartburn. It is also commonly used in a regimen to prevent allergic reactions. |
|
| CAS_Registry |
51481-61-9 |
|
| CHEBI_ID |
CHEBI:3699 |
|
| Chemical_Formula |
C10H16N6S |
|
| code |
C374 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine's ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor. (NCI04) |
|
| Display_Name |
Cimetidine |
|
| FDA_UNII_Code |
80061L1WGD |
|
| Has_Salt_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Cimetidine |
|
| Legacy Concept Name |
Cimetidine |
|
| Maps_To |
Cimetidine |
|
| NCI_Drug_Dictionary_ID |
39185 |
|
| NSC Number |
335308 |
|
| PDQ_Closed_Trial_Search_ID |
39185 |
|
| PDQ_Open_Trial_Search_ID |
39185 |
|
| Preferred_Name |
Cimetidine |
|
| prefixIRI |
NCIT:C374 |
|
| prefLabel |
Cimetidine |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0008783 |
|
| subClassOf |