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Human Interaction Network Ontology
| Preferred Name | Molecules associated with elastic fibres | |
| Synonyms |
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| Definitions |
Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 Proteins found associated with microfibrils include vitronectin (Dahlback et al. 1990), latent transforming growth factor beta-binding proteins (Kielty et al. 2002, Munger & Sheppard 2011), emilin (Bressan et al. 1993, Mongiat et al. 2000), members of the microfibrillar-associated proteins (MFAPs, Gibson et al.1996), and fibulins (Roark et al. 1995, Yanagisawa et al. 2002). The significance of these interactions is not well understood. Proteoglycans such as versican (Isogai et al. 2002), biglycan, and decorin (Reinboth et al. 2002) can interact with the microfibrils. They confer specific properties including hydration, impact absorption, molecular sieving, regulation of cellular activities, mediation of growth factor association, and release and transport within the extracellular matrix (Buczek-Thomas et al. 2002). In addition, glycosaminoglycans have been shown to interact with tropoelastin through its lysine side chains (Wu et al. 1999) regulating tropoelastin assembly (Tu and Weiss, 2008). Reviewed: Muiznieks, Lisa, 2012-11-02 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0026194 |
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| comment |
Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 Proteins found associated with microfibrils include vitronectin (Dahlback et al. 1990), latent transforming growth factor beta-binding proteins (Kielty et al. 2002, Munger & Sheppard 2011), emilin (Bressan et al. 1993, Mongiat et al. 2000), members of the microfibrillar-associated proteins (MFAPs, Gibson et al.1996), and fibulins (Roark et al. 1995, Yanagisawa et al. 2002). The significance of these interactions is not well understood.
Proteoglycans such as versican (Isogai et al. 2002), biglycan, and decorin (Reinboth et al. 2002) can interact with the microfibrils. They confer specific properties including hydration, impact absorption, molecular sieving, regulation of cellular activities, mediation of growth factor association, and release and transport within the extracellular matrix (Buczek-Thomas et al. 2002). In addition, glycosaminoglycans have been shown to interact with tropoelastin through its lysine side chains (Wu et al. 1999) regulating tropoelastin assembly (Tu and Weiss, 2008). Reviewed: Muiznieks, Lisa, 2012-11-02
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| definition source |
Pubmed1689758 Pubmed11723132 Pubmed10821830 Pubmed12429738 Pubmed10419484 Pubmed8458869 Pubmed18228265 Pubmed12124775 Reactome, http://www.reactome.org Pubmed18547105 Pubmed7534784 Pubmed21900405 Pubmed8557636 Pubmed12082143 Pubmed11805834
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| label |
Molecules associated with elastic fibres
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| located_in | ||
| prefixIRI |
HINO:0026194
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| prefLabel |
Molecules associated with elastic fibres
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| seeAlso |
Reactome Database ID Release 432129379 ReactomeREACT_150331
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0021725 http://purl.obolibrary.org/obo/HINO_0021723 http://purl.obolibrary.org/obo/HINO_0021727 http://purl.obolibrary.org/obo/HINO_0021721 http://purl.obolibrary.org/obo/HINO_0021691 http://purl.obolibrary.org/obo/HINO_0021695 http://purl.obolibrary.org/obo/HINO_0021715 http://purl.obolibrary.org/obo/HINO_0021714 |
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