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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Latent TGF-beta-3 binds integrins | |
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| Definitions |
Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 The LAPs of TGF-beta1 and TGF-beta3 contain RGD sequences near the carboxyl termini that are bound by RGD-binding integrins. LAP3 binds alphaVBeta1, 3, 5 and 6 (Ludbrook et al. 2003) and 8 (Kitamura et al. 2011). Binding to integrins alphaVBeta6 and alphaVBeta8 leads to TGF-beta activation. Reviewed: Muiznieks, Lisa, 2012-11-02 |
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http://purl.obolibrary.org/obo/HINO_0021727 |
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| comment |
Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 The LAPs of TGF-beta1 and TGF-beta3 contain RGD sequences near the carboxyl termini that are bound by RGD-binding integrins. LAP3 binds alphaVBeta1, 3, 5 and 6 (Ludbrook et al. 2003) and 8 (Kitamura et al. 2011). Binding to integrins alphaVBeta6 and alphaVBeta8 leads to TGF-beta activation. Reviewed: Muiznieks, Lisa, 2012-11-02
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| definition source |
Pubmed12358597 Reactome, http://www.reactome.org Pubmed21646718
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| label |
Latent TGF-beta-3 binds integrins
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| prefixIRI |
HINO:0021727
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| prefLabel |
Latent TGF-beta-3 binds integrins
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| seeAlso |
Reactome Database ID Release 432396029 ReactomeREACT_150337
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