Link to this page
Human Interaction Network Ontology
Last uploaded:
June 27, 2014
Jump to:
| Preferred Name | Latent TGF-beta-1 binds integrins | |
| Synonyms |
|
|
| Definitions |
Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 The LAPs of TGF beta-1 and TGF beta-3 contain RGD sequences near the carboxyl termini that are bound by RGD binding integrins. The TGF beta-1 form of LAP (LAP1) binds the integrins alphaVBeta1 (Munger et al. 1998), alphaVBeta3 (Ludbrook et al. 2003), alphaVBeta5 (Munger et al. 1998), alphaVBeta6 (Munger et al. 1999, Araya et al. 2006), alphaVBeta8 (Mu et al. 2002, Araya et al. 2006) and alpha8Beta1 (Lu et al. 2002). Binding to integrins alphaVBeta6 and alphaVBeta8 leads to TGF beta activation. Reviewed: Muiznieks, Lisa, 2012-11-02 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0021721 |
|
| comment |
Edited: Jupe, S, 2012-11-12 Authored: Jupe, S, 2012-04-30 The LAPs of TGF beta-1 and TGF beta-3 contain RGD sequences near the carboxyl termini that are bound by RGD binding integrins. The TGF beta-1 form of LAP (LAP1) binds the integrins alphaVBeta1 (Munger et al. 1998), alphaVBeta3 (Ludbrook et al. 2003), alphaVBeta5 (Munger et al. 1998), alphaVBeta6 (Munger et al. 1999, Araya et al. 2006), alphaVBeta8 (Mu et al. 2002, Araya et al. 2006) and alpha8Beta1 (Lu et al. 2002). Binding to integrins alphaVBeta6 and alphaVBeta8 leads to TGF beta activation. Reviewed: Muiznieks, Lisa, 2012-11-02
|
|
| definition source |
Pubmed16877343 Pubmed12358597 Pubmed10025398 Reactome, http://www.reactome.org Pubmed9725916 Pubmed11970960 Pubmed12415008
|
|
| has input | ||
| has output | ||
| label |
Latent TGF-beta-1 binds integrins
|
|
| prefixIRI |
HINO:0021721
|
|
| prefLabel |
Latent TGF-beta-1 binds integrins
|
|
| seeAlso |
Reactome Database ID Release 432395320 ReactomeREACT_150434
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |