loading...| Preferred Name | DAP12 interactions | |
| Synonyms |
|
|
| Definitions |
DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cells. It mediates signalling for multiple cell-surface receptors expressed by these cells, associating with receptor chains through complementary charged transmembrane amino acids that form a salt-bridge in the context of the hydrophobic lipid bilayer (Lanier et al. 1998). DAP12 homodimers associate with a variety of receptors expressed by macrophages, monocytes and myeloid cells including TREM2, Siglec H and SIRP-beta, as well as activating KIR, LY49 and the NKG2C proteins expressed by NK cells. DAP12 is expressed at the cell surface, with most of the protein lying on the cytoplasmic side of the membrane (Turnbull & Colonna 2007, Tessarz & Cerwenka 2008). Edited: Garapati, P V, 2012-05-25 Reviewed: Lanier, Lewis L, 2012-08-09 Authored: Garapati, P V, 2012-05-25 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0022269 |
|
| comment |
DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cells. It mediates signalling for multiple cell-surface receptors expressed by these cells, associating with receptor chains through complementary charged transmembrane amino acids that form a salt-bridge in the context of the hydrophobic lipid bilayer (Lanier et al. 1998). DAP12 homodimers associate with a variety of receptors expressed by macrophages, monocytes and myeloid cells including TREM2, Siglec H and SIRP-beta, as well as activating KIR, LY49 and the NKG2C proteins expressed by NK cells. DAP12 is expressed at the cell surface, with most of the protein lying on the cytoplasmic side of the membrane (Turnbull & Colonna 2007, Tessarz & Cerwenka 2008). Edited: Garapati, P V, 2012-05-25 Reviewed: Lanier, Lewis L, 2012-08-09 Authored: Garapati, P V, 2012-05-25 |
|
| definition source |
Pubmed9490415 Reactome, http://www.reactome.org Pubmed19120482 Pubmed18192027 Pubmed17220916 Pubmed15884055 |
|
| label |
DAP12 interactions |
|
| located_in | ||
| prefixIRI |
HINO:0022269 |
|
| prefLabel |
DAP12 interactions |
|
| seeAlso |
Reactome Database ID Release 432172127 ReactomeREACT_147694 |
|
| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0007812 http://purl.obolibrary.org/obo/HINO_0007814 http://purl.obolibrary.org/obo/HINO_0007811 http://purl.obolibrary.org/obo/HINO_0007813 http://purl.obolibrary.org/obo/HINO_0007805 http://purl.obolibrary.org/obo/HINO_0007807 http://purl.obolibrary.org/obo/HINO_0007809 http://purl.obolibrary.org/obo/HINO_0007803 http://purl.obolibrary.org/obo/HINO_0007801 http://purl.obolibrary.org/obo/HINO_0010391 http://purl.obolibrary.org/obo/HINO_0022249 http://purl.obolibrary.org/obo/HINO_0007782 http://purl.obolibrary.org/obo/HINO_0007783 http://purl.obolibrary.org/obo/HINO_0007781 http://purl.obolibrary.org/obo/HINO_0007780 |