loading...| Preferred Name | Interaction of DAP12 and KIR2DS2 | |
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| Definitions |
has a Stoichiometric coefficient of 2 Killer cell immunoglobulin-like two-domain short-tail receptor 2 (KIR2DS2) is an activating KIR receptor invariably expressed on the cell surface of NK cells and subsets of T cells. The ligand specificity of KIR2DS2 is unknown; it does not bind the HLA-Cw3 molecules recognised by the inhibitory receptor KIR2DL2, despite 99% extracellular amino acid identity (Saulquin et al. 2003). In the presence of DAP12, cross-linking of KIR2DS2 with monoclonal antibody leads to phosphorylation of JNK and ERK and activation of both cytotoxicity and IFN-production. Edited: Garapati, P V, 2012-05-25 Reviewed: Lanier, Lewis L, 2012-08-09 Authored: Garapati, P V, 2012-05-25 |
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http://purl.obolibrary.org/obo/HINO_0007814 |
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has a Stoichiometric coefficient of 2 Killer cell immunoglobulin-like two-domain short-tail receptor 2 (KIR2DS2) is an activating KIR receptor invariably expressed on the cell surface of NK cells and subsets of T cells. The ligand specificity of KIR2DS2 is unknown; it does not bind the HLA-Cw3 molecules recognised by the inhibitory receptor KIR2DL2, despite 99% extracellular amino acid identity (Saulquin et al. 2003). In the presence of DAP12, cross-linking of KIR2DS2 with monoclonal antibody leads to phosphorylation of JNK and ERK and activation of both cytotoxicity and IFN-production. Edited: Garapati, P V, 2012-05-25 Reviewed: Lanier, Lewis L, 2012-08-09 Authored: Garapati, P V, 2012-05-25 |
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| definition source |
Reactome, http://www.reactome.org Pubmed12668644 |
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| label |
Interaction of DAP12 and KIR2DS2 |
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| prefixIRI |
HINO:0007814 |
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| prefLabel |
Interaction of DAP12 and KIR2DS2 |
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| seeAlso |
Reactome Database ID Release 43210309 ReactomeREACT_147777 |
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