CLM7/TREM5 is a member of the CMRF-35/immune receptor expressed by myeloid cell (IREM) multigene family of immune receptors expressed on myeloid cells. It has a basic residue in its transmembrane domain and a functional tyrosine-based motif in its short cytoplasmic tail. This structural arrangement confers CLM7 the ability to signal through two independent pathways: one through associating with activating adaptor protein DAP12 and the other through the tyrosine motif in its cytoplasmic tail (Martinez-Barriocanal & Sayos 2006). Edited: Garapati, P V, 2012-05-25 Reviewed: Lanier, Lewis L, 2012-08-09 Authored: Garapati, P V, 2012-05-25

http://purl.obolibrary.org/obo/HINO_0007777

CLM7/TREM5 is a member of the CMRF-35/immune receptor expressed by myeloid cell (IREM) multigene family of immune receptors expressed on myeloid cells. It has a basic residue in its transmembrane domain and a functional tyrosine-based motif in its short cytoplasmic tail. This structural arrangement confers CLM7 the ability to signal through two independent pathways: one through associating with activating adaptor protein DAP12 and the other through the tyrosine motif in its cytoplasmic tail (Martinez-Barriocanal & Sayos 2006).

Edited: Garapati, P V, 2012-05-25

Reviewed: Lanier, Lewis L, 2012-08-09

Authored: Garapati, P V, 2012-05-25

Pubmed16920917

Reactome, http://www.reactome.org

http://purl.obolibrary.org/obo/HINO_0018207

http://purl.obolibrary.org/obo/UniProt_A8K4G0

http://purl.obolibrary.org/obo/HINO_0002838

Interaction of DAP12 and CLM7

HINO:0007777

Interaction of DAP12 and CLM7

Reactome Database ID Release 432426566

ReactomeREACT_147706

http://purl.obolibrary.org/obo/INO_0000040