has a Stoichiometric coefficient of 2 Killer cell immunoglobulin-like two-domain short-tail receptor 5 (KIR2DS5) is an activating KIR receptor expressed on natural killer (NK) cells and subpopulations of T lymphocytes (Nowak et al. 2010). KIR2DS5 has two Ig domains of the D1-D2 type, a short cytoplasmic tail and a positive charged transmembrane (TM) portion.<br>No physiological ligand has yet been identified for KIR2DS5 but it is able to associate with DAP12 and induce both cytotoxicity and cytokine release when KIR2DS5 is cross-linked with monoclonal antibody (Della Chiesa et al. 2008). Edited: Garapati, P V, 2012-05-25 Reviewed: Lanier, Lewis L, 2012-08-09 Authored: Garapati, P V, 2012-05-25

http://purl.obolibrary.org/obo/HINO_0007807

has a Stoichiometric coefficient of 2

Killer cell immunoglobulin-like two-domain short-tail receptor 5 (KIR2DS5) is an activating KIR receptor expressed on natural killer (NK) cells and subpopulations of T lymphocytes (Nowak et al. 2010). KIR2DS5 has two Ig domains of the D1-D2 type, a short cytoplasmic tail and a positive charged transmembrane (TM) portion.
No physiological ligand has yet been identified for KIR2DS5 but it is able to associate with DAP12 and induce both cytotoxicity and cytokine release when KIR2DS5 is cross-linked with monoclonal antibody (Della Chiesa et al. 2008).

Edited: Garapati, P V, 2012-05-25

Reviewed: Lanier, Lewis L, 2012-08-09

Authored: Garapati, P V, 2012-05-25

Reactome, http://www.reactome.org

Pubmed18624290

Pubmed20865034

http://purl.obolibrary.org/obo/HINO_0018207

http://purl.obolibrary.org/obo/UniProt_Q14953

http://purl.obolibrary.org/obo/HINO_0002750

Interaction of DAP12 and KIR2DS5

HINO:0007807

Interaction of DAP12 and KIR2DS5

Reactome Database ID Release 432272668

ReactomeREACT_147742

http://purl.obolibrary.org/obo/INO_0000040