Human Interaction Network Ontology

Last uploaded: June 27, 2014
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Id http://purl.obolibrary.org/obo/HINO_0010391
http://purl.obolibrary.org/obo/HINO_0010391
Preferred Name

Interaction of DAP12 and SIRP beta
Definitions
SIRP beta , also named CD172b, is expressed mainly on myeloid cells and has a very short cytoplasmic region of only six amino acids, lacking the signaling motifs for association with phosphatases that are found in the highly related SIRP alpha receptor. Instead, SIRP associates with a dimeric protein DAP12 to transmit activating signals via an ITAM in the cytoplasmic domain of DAP12. A positively charged amino acid in the transmembrane domain of DAP12 associate with a basic amino acid in SIRP beta's transmembrane region. Reviewed: Barclay, AN, 2010-05-20 Edited: Garapati, P V, 2009-02-12 18:17:40 Authored: Garapati, P V, 2009-02-12 18:17:40
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Interaction of DAP12 and SIRP beta
comment
SIRP beta , also named CD172b, is expressed mainly on myeloid cells and has a very short cytoplasmic region of only six amino acids, lacking the signaling motifs for association with phosphatases that are found in the highly related SIRP alpha receptor. Instead, SIRP associates with a dimeric protein DAP12 to transmit activating signals via an ITAM in the cytoplasmic domain of DAP12. A positively charged amino acid in the transmembrane domain of DAP12 associate with a basic amino acid in SIRP beta's transmembrane region.
Reviewed: Barclay, AN, 2010-05-20
Edited: Garapati, P V, 2009-02-12 18:17:40
Authored: Garapati, P V, 2009-02-12 18:17:40
prefLabel
Interaction of DAP12 and SIRP beta
definition source
Pubmed10940905
Pubmed16691243
Reactome, http://www.reactome.org
Pubmed10604985
prefixIRI
HINO:0010391
seeAlso
ReactomeREACT_23798
Reactome Database ID Release 43210274
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