loading...| Preferred Name | Interaction of DAP12 and MDL-1 | |
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Edited: Garapati, P V, 2012-05-25 Myeloid DAP12-associating lectin (MDL)-1, also designated CLEC5A, is a type II transmembrane protein belonging to the C-type lectin superfamily and expressed exclusively in monocytes and macrophages. MDL-1 contains a charged residue in the transmembrane region and this enables it to pair with DAP12 dimers. MDL-1's natural mammalian ligand is unknown, but MDL-1 is a receptor for Dengue virus CLEC5A is critical for dengue-virus-induced lethal disease (Chen et al 2008). Engagement with DAP12 has been shown to regulate osteoclastogenesis and myeloid cell-associated inflammatory responses (Bakker et al. 1999, Aoki et al. 2009, Inui et al 2009, Joyce-Shaikh et al. 2010, Cheung et al. 2011). Reviewed: Lanier, Lewis L, 2012-08-09 Authored: Garapati, P V, 2012-05-25 |
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http://purl.obolibrary.org/obo/HINO_0007811 |
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Edited: Garapati, P V, 2012-05-25 Myeloid DAP12-associating lectin (MDL)-1, also designated CLEC5A, is a type II transmembrane protein belonging to the C-type lectin superfamily and expressed exclusively in monocytes and macrophages. MDL-1 contains a charged residue in the transmembrane region and this enables it to pair with DAP12 dimers. MDL-1's natural mammalian ligand is unknown, but MDL-1 is a receptor for Dengue virus CLEC5A is critical for dengue-virus-induced lethal disease (Chen et al 2008). Engagement with DAP12 has been shown to regulate osteoclastogenesis and myeloid cell-associated inflammatory responses (Bakker et al. 1999, Aoki et al. 2009, Inui et al 2009, Joyce-Shaikh et al. 2010, Cheung et al. 2011). Reviewed: Lanier, Lewis L, 2012-08-09 Authored: Garapati, P V, 2012-05-25 |
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Pubmed22005300 Pubmed19074552 Reactome, http://www.reactome.org Pubmed10449773 Pubmed20212065 Pubmed19251634 Pubmed18496526 Pubmed15884055 |
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Interaction of DAP12 and MDL-1 |
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| prefixIRI |
HINO:0007811 |
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Interaction of DAP12 and MDL-1 |
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ReactomeREACT_147800 Reactome Database ID Release 43210271 |
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