A nitrogenous compound containing a carbonyl group attached to two amine groups with osmotic diuretic activity. In vivo, urea is formed in the liver via the urea cycle from ammonia and is the final end product of protein metabolism. Administration of urea elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain, cerebrospinal fluid and eye, into interstitial fluid and plasma, thereby decreasing pressure in those tissues and increasing urine outflow.

http://purl.obolibrary.org/obo/NCIT_C29531

A substance formed by the breakdown of protein in the liver. The kidneys filter carbamide out of the blood and into the urine. Carbamide can also be made in the laboratory. A topical form of carbamide is being studied in the treatment of hand-foot syndrome (pain, swelling, numbness, tingling, or redness of the hands or feet that may occur as a side effect of certain anticancer drugs).

57-13-6

CHEBI:16199

CH4N2O

C29531

FDA

A nitrogenous compound containing a carbonyl group attached to two amine groups with osmotic diuretic activity. In vivo, urea is formed in the liver via the urea cycle from ammonia and is the final end product of protein metabolism. Administration of urea elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain, cerebrospinal fluid and eye, into interstitial fluid and plasma, thereby decreasing pressure in those tissues and increasing urine outflow.

8W8T17847W

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C176424

Urea

Carbamide

40286

34375

40286

40286

Urea

NCIT:C29531

Urea

Organic Chemical

Pharmacologic Substance

C0041942

http://purl.obolibrary.org/obo/NCIT_C49187