loading...| Preferred Name |
Phenobarbital |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClasscb7a89af_955f_4b5d_a48a_77e66e590119 |
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| Chinese |
苯巴比妥 |
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| label |
Phenobarbital |
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| MESH_Definition |
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. |
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| NCIt_Definition |
A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization. |
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| NICE_guidance |
Do not routinely monitor AED levels during pregnancy. If seizures increase or are likely to increase, monitoring AED levels (particularly levels of lamotrigine and phenytoin, which may be particularly affected in pregnancy) may be useful when making dose adjustments. [new 2012] 怀孕期间不要常规监测抗癫痫药物水平。如果癫痫发作增加或可能增加，监测 AED 水平（尤其是拉莫三嗪和苯妥英的水平，其在怀孕期间可能受到特别影响）在调整剂量时可能有用。 [2012年新] nice.org.uk/guidance/cg137 |
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| prefLabel |
Phenobarbital |
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| ROCG_Guidance |
[GRADES OF RECOMMENDATION:C] Women taking enzyme-inducing AEDs (carbamazepine, phenytoin, phenobarbital, primidone, oxcarbazepine, topiramate and eslicarbazepine) should be counselled about the risk of failure with some hormonal contraceptives. 【推荐等级：C】应告知服用酶诱导型AEDs（卡马西平、苯妥英、苯巴比妥、扑米酮、奥卡西平、托吡酯、艾司利卡西平）的WWE避孕失败的风险。 https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/epilepsy-in-pregnancy-green-top-guideline-no-68/ |
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| Synonyms |
Phenobarbital (substance) 5-Phenyl-5-ethylbarbituric acid Acid Phenylethylbarbituric Phenylethylmalonylurea Phenemal Phenylethylbarbiturate Phenobarbital Phenobarbitol 5-Ethyl-5-phenylbarbituric acid 5-Ethyl-5-phenyl-pyrimidine-246-trione Phenyläthylbarbitursäure 5-Ethyl-5-phenyl-246(1H3H5H)-pyrimidinetrione 5-ethyl-5-phenyl-246(1H3H5H)-pyrimidinetrione 246(1H3H5H)-Pyrimidinetrione 5-ethyl-5-phenyl- Phenobarbital-containing product PHENOBARBITAL 128143 Phenobarbitone PHENO phenobarbital Phenylethylbarbitursäure 5-ethyl-5-phenylpyrimidine-246(1H3H5H)-trione PHENobarbital Fenobarbital Phenobarbituric Acid 9848 Phenylbarbital Product containing phenobarbital (medicinal product) 50-06-6 Phenylethylbarbituric Acid Phenobarbital Monosodium Salt Phenobarbital Sodium Gardenal Monosodium Salt Phenobarbital Sodium Phenobarbital Luminal Hysteps |
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