loading...| Preferred Name |
Amiodarone |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass39f879ce_8cbf_4320_af71_983c6e77c271 |
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| Chinese |
胺碘酮 |
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| label |
Amiodarone |
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| MESH_Definition |
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance. |
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| NCIt_Definition |
An iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors. |
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| prefLabel |
Amiodarone |
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| Synonyms |
2-n-Butyl-35-diiodo-4-N-diethylaminoethoxy-3-benzoylbenzofuran Amiodarone-containing product Amiodarone (substance) Methanone (2-butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-35-diiodophenyl)- amiodarone Amiodaronum 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-35-diiodophenyl ketone Product containing amiodarone (medicinal product) 2-Butyl-3-(35-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran Amiodarona |
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| subClassOf |