loading...| Preferred Name |
Cell death |
|
| Synonyms |
|
|
| ID |
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_6e11a25e_c888_474f_98db_38865e6df5ce |
|
| hasDbXref | ||
| isDefinedBy |
The most satisfactory definition of cell death, and the one that would be the most valuable to know therapeutically, is the point at which the cell becomes unable to recover its normal morphology and function even if all processes leading to dissoution are stopped pharmacologically (the point of no return). Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo. |
|
| label |
Cell death |
|
| prefixIRI |
OWLClass_6e11a25e_c888_474f_98db_38865e6df5ce |
|
| prefLabel |
Cell death |
|
| references |
Lipton, P. (1999). Ischemic cell death in brain neurons. Physiological reviews, 79(4), 1431-1568. |
|
| synonyms |
Cell damage |
|
| subClassOf |
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_23e71a33_674f_4315_a558_53eb2597b5d2 |