loading...| Preferred Name |
Nephrotic Syndrome |
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| Synonyms |
Nephrosis |
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| Definitions |
Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria >3.5 g per 24 hours (in children, >40 mg/m2/hr or PCR >2000 mg/g [>200 mg/mmol] or >300 mg/dl or 3+ on urine dipstick) plus hypoalbuminemia (<3gm/dl) and edema. |
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| ID |
http://purl.obolibrary.org/obo/SCDO_0000796 |
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| curator note |
Suggest update to description in the HPO |
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| database cross reference |
HP:0000100 |
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| definition |
Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria >3.5 g per 24 hours (in children, >40 mg/m2/hr or PCR >2000 mg/g [>200 mg/mmol] or >300 mg/dl or 3+ on urine dipstick) plus hypoalbuminemia (<3gm/dl) and edema. |
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| definition source | ||
| diagnosed using measurement |
http://purl.obolibrary.org/obo/SCDO_0001207 |
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| diagnosed using tool | ||
| existence in other ontologies |
Suggest update to description |
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| has age of onset |
Nephrotic syndrome related to sickle cell disease typically occurs in adulthood and preceded by lesser degree of proteinuria, other forms may occur at any age with different histologic lesions occurring at different ages. |
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| hasExactSynonym |
Nephrosis |
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| in guideline |
http://purl.obolibrary.org/obo/SCDO_1000150 |
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| is caused by |
Variety of causes - in sickle cell disease, most common lesion is focal segmental glomerulosclerosis (FSGS). Other causes may be other forms of primary glomerular disease including membranous nephropathy, minimmal change disease, membranoproliferative glomerulonephritis. Secondary forms may result from diabetes, amyloidosis. |
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| is characterised by |
Heavy proteinuria, edema, hyperlipidemia. May also be associated with hypertension and increased risk of venous thrombosis. |
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| prefixIRI |
SCDO:0000796 |
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| prefLabel |
Nephrotic Syndrome |
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| rdfs:label |
Nephrotic Syndrome |
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| treated with | ||
| subClassOf |