Physician Data Query

Last uploaded: July 6, 2018
Preferred Name

verapamil

Synonyms

Verapamil SR

Definitions

A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39730&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39730&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C928" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039730

altLabel

Verapamil SR

alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile

CAS Registry

52-53-9

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041523

http://purl.bioontology.org/ontology/PDQ/CDR0000041447

http://purl.bioontology.org/ontology/PDQ/CDR0000041462

http://purl.bioontology.org/ontology/PDQ/CDR0000041513

http://purl.bioontology.org/ontology/PDQ/CDR0000040143

http://purl.bioontology.org/ontology/PDQ/CDR0000041262

http://purl.bioontology.org/ontology/PDQ/CDR0000041095

http://purl.bioontology.org/ontology/PDQ/CDR0000041511

cui

C1527129

C0042523

Date last modified

2006-12-19

definition

A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39730&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39730&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C928" NCI Thesaurus)

Legacy PDQ ID

2392

LT

TRD

NCI ID

C928

notation

CDR0000039730

ORIG STY

Drug/agent

prefLabel

verapamil

tui

T109

T121

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.471.683.953 RH-MESH LOOM
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http://www.drugbank.ca/drugs/DB00661 FTC LOOM
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http://id.loc.gov/authorities/subjects/sh93000011 FAST-TOPICAL LOOM