loading...| Preferred Name |
Amyotrophic Lateral Sclerosis |
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| Synonyms |
spinal; sclerosis, lateral (amyotrophic) |
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| Definitions |
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SP (source : MSH) |
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| ID |
http://doe-generated-ontology.com/OntoAD#C0002736 |
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| altLabel |
spinal; sclerosis, lateral (amyotrophic) ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis/Progressive Muscular Atrophy MOTOR NEURON DIS AMYOTROPHIC LATERAL SCLEROSIS LOU GEHRIG DIS palsy; creeping maladie du neurone moteur bulbaire Maladie de Charcot Lou Gehrig's disease (ALS) Motor Neuron Disease, Amyotrophic Lateral Sclerosis Gehrig's Disease ALS Amyotroph lat sclerosis GEHRIGS DIS amyotrophy; lateral sclerosis SLA (Sclérose Latérale Amyotrophique) Bulbar motor neuron disease Amyotrophic sclerosis ALS (Amyotrophic Lateral Sclerosis) Maladie de Lou Gehrig |
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| clinically_associated_with | ||
| definition |
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SP (source : MSH) |
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| disease_has_associated_anatomic_site | ||
| has_finding_site | ||
| has_severity | ||
| hiddenLabel |
AmyotrophicLateralSclerosis ScléroseLatéraleAmyotrophique |
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| manifestation_of | ||
| may_be_treated_by | ||
| prefixIRI |
OntoAD:C0002736 |
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| prefLabel |
Sclérose latérale amyotrophique Amyotrophic Lateral Sclerosis |
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| subClassOf |