loading...| Preferred Name |
nicotine |
|
| Synonyms |
rac-3-(1-methylpyrrolidin-2-yl)pyridine (RS)-nicotine (R,S)-nicotine (+-)-nicotine (+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine nicotin nikotin Nicotine Polacrilex Habitrol Nicorette Nicotrol Inhaler Nicotine bitartrate L-Nicotine Nicorette Plus Nicotine Alkaloid Nicoderm Nicoderm Cq Fumetobac Nicotrol Nicocide Nicotrol Ns Nikotyna Nicotina |
|
| Definitions |
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. (PubChem) Pharmacology: Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia. Mechanism of action: Nicotine binds to the nicotinic acetylcholine receptor. Stimulation of nicotinic receptors leads to a variety of cholinergic and adrenergic effects; tachycardia or bradycardia mediated by either stimulation or interference with sympathetic or parasympathetic pathways, stimulation of receptors in the carotic and aortic bodies, release of epinephrine from the adrenal medulla, and stimulation of the chemoreceptor-trigger zone. Drug type: Approved. Small Molecule. Drug category: Anti-craving Agents. Autonomic drugs. Central Nervous System Agents. Ganglionic Stimulants. Nicotinic Agonists Street names: Black Leaf, Black Leaf 40, Campbell's Nico-Soap, Commit, Destruxol Orchid Spray, Emo-Nik, Flux Maag, Mach-Nic, Niagara P,A, Dust, Nic-Sal, Nico-Dust, Nico-Fume, Ortho N-4 Dust, Ortho N-5 Dust, Prostep, Tendust A racemate composed of equimolar amounts of (R)- and (S)-nicotine. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_18723 |
|
| comment |
Street names: Black Leaf, Black Leaf 40, Campbell's Nico-Soap, Commit, Destruxol Orchid Spray, Emo-Nik, Flux Maag, Mach-Nic, Niagara P,A, Dust, Nic-Sal, Nico-Dust, Nico-Fume, Ortho N-4 Dust, Ortho N-5 Dust, Prostep, Tendust |
|
| createdDate |
March 5, 2010 |
|
| database_cross_reference |
PMID:15961264 PMID:15251917 PMID:9450943 PMID:8764340 PMID:19465085 PMID:12700710 UM-BBD_compID:c0468 PMID:22589423 PMID:7896575 PMID:11801622 Wikipedia:Nicotine PMID:22218403 CAS:22083-74-5 PMID:22770225 PMID:10751565 PMID:11559179 PMID:18383130 PMID:18922921 PMID:11192937 PMID:22377934 PMID:19100331 PMID:21945235 PMID:22930863 PMID:7097594 PMID:17167832 PMID:12965231 HMDB:HMDB0014330 PMID:23108361 PMID:22855884 PMID:15313135 PMID:22585541 PMID:17498149 PMID:23117126 PMID:9203638 PMID:16496293 PMID:8156919 Beilstein:82108 PMID:7564279 PMID:16950410 PMID:11714820 PMID:11471991 DrugBank:DB00184 PMID:14715938 PMID:15707677 PMID:9621392 PMID:11818389 PMID:19287496 PMID:8545712 PMID:22129149 PMID:20528766 PMID:12197757 PMID:19389046 PMID:22573728 PMID:15183514 PMID:15458549 PMID:22448647 PMID:15960296 PMID:22792725 PMID:18651995 PMID:18311975 PMID:11719700 Beilstein:82111 PMID:17942810 PMID:15894687 PMID:20338106 PMID:22935730 KNApSAcK:C00002057 KEGG:C16150 PMID:21822688 PMID:17206646 Reaxys:82108 PMID:22459798 PMID:18380035 PMID:22331007 PMID:22529223 PMID:7566693 PMID:18077004 PMID:11682702 PMID:11860617 PMID:21636612 PMID:17438652 PMID:7807214 |
|
| definition |
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. (PubChem) Pharmacology: Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia. Mechanism of action: Nicotine binds to the nicotinic acetylcholine receptor. Stimulation of nicotinic receptors leads to a variety of cholinergic and adrenergic effects; tachycardia or bradycardia mediated by either stimulation or interference with sympathetic or parasympathetic pathways, stimulation of receptors in the carotic and aortic bodies, release of epinephrine from the adrenal medulla, and stimulation of the chemoreceptor-trigger zone. Drug type: Approved. Small Molecule. Drug category: Anti-craving Agents. Autonomic drugs. Central Nervous System Agents. Ganglionic Stimulants. Nicotinic Agonists |
|
| has characteristic | ||
| has exact synonym |
rac-3-(1-methylpyrrolidin-2-yl)pyridine |
|
| has part | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_50905 http://purl.obolibrary.org/obo/CHEBI_47958 http://purl.obolibrary.org/obo/CHEBI_49110 http://purl.obolibrary.org/obo/CHEBI_50846 http://purl.obolibrary.org/obo/CHEBI_35474 http://purl.obolibrary.org/obo/CHEBI_52290 |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
(RS)-nicotine (R,S)-nicotine (+-)-nicotine (+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine nicotin nikotin |
|
| hasExternalSource |
DB00184 |
|
| hasStreetName |
Mach-Nic Black Leaf 40 Destruxol Orchid Spray Nic-Sal Nico-Dust Flux Maag Niagara P,A Dust Prostep Campbell's Nico-Soap Emo-Nik Tendust Nico-Fume Black Leaf Ortho N-4 Dust Ortho N-5 Dust Commit |
|
| id |
CHEBI:18723 |
|
| in_subset | ||
| label |
Nicotine nicotine |
|
| modifiedDate |
June 30, 2010 |
|
| notation |
CHEBI:18723 |
|
| prefLabel |
nicotine |
|
| synonym |
Nicotine Polacrilex Habitrol Nicorette Nicotrol Inhaler Nicotine bitartrate L-Nicotine Nicorette Plus Nicotine Alkaloid Nicoderm Nicoderm Cq Fumetobac Nicotrol Nicocide Nicotrol Ns Nikotyna Nicotina |
|
| subClassOf |