Preferred Name |
G-protein coupled receptor |
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Synonyms |
fam:GPCR 7TM receptor seven-transmembrane receptor |
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Definitions |
Category=family. Classification based on GRAFS system. [PMID:12761335] A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit. |
|
ID |
http://purl.obolibrary.org/obo/PR_000030035 |
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comment |
Category=family. Classification based on GRAFS system. [PMID:12761335] |
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capable of | ||
database_cross_reference |
IUPHARfam:694 |
|
definition |
A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit. |
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has exact synonym |
fam:GPCR |
|
has_broad_synonym |
7TM receptor seven-transmembrane receptor |
|
has_obo_namespace |
protein |
|
id |
PR:000030035 |
|
label |
G-protein coupled receptor |
|
notation |
PR:000030035 |
|
prefLabel |
G-protein coupled receptor |
|
subClassOf |
http://purl.obolibrary.org/obo/PR_000000001 |