loading...| Preferred Name |
hematopoietic stem cell |
|
| Synonyms |
blood forming stem cell hemopoietic stem cell HSC colony forming unit hematopoietic |
|
| Definitions |
Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. |
|
| ID |
http://purl.obolibrary.org/obo/CL_0000037 |
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| comment |
Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. |
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| capable of | ||
| database_cross_reference |
MESH:D006412 BTO:0000725 CALOHA:TS-0448 VHOG:0001485 FMA:70337 FMA:86475 |
|
| definition |
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. |
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| develops_from | ||
| has_exact_synonym |
blood forming stem cell hemopoietic stem cell HSC |
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| has_related_synonym |
colony forming unit hematopoietic |
|
| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim |
|
| label |
hematopoietic stem cell |
|
| lacks_plasma_membrane_part |
http://purl.obolibrary.org/obo/PR_000001289 http://purl.obolibrary.org/obo/PR_000002978 http://purl.obolibrary.org/obo/PR_000001012 http://purl.obolibrary.org/obo/PR_000001020 http://purl.obolibrary.org/obo/PR_000001024 http://purl.obolibrary.org/obo/PR_000002981 http://purl.obolibrary.org/obo/PR_000001839 http://purl.obolibrary.org/obo/PR_000001002 http://purl.obolibrary.org/obo/PR_000001004 http://purl.obolibrary.org/obo/PR_000001889 |
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| prefixIRI |
CL:0000037 |
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| prefLabel |
hematopoietic stem cell |
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| present in taxon | ||
| treeView | ||
| subClassOf |
http://purl.obolibrary.org/obo/CL_0000723 http://purl.obolibrary.org/obo/CL_0008001 |