Preferred Name |
Vinblastine |
|
Synonyms |
VINBLASTINE Vinblastine Vincaleucoblastine vinblastine VLB |
|
Definitions |
A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04) |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C930 |
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Accepted_Therapeutic_Use_For |
Bladder cancer; Breast cancer; Choriocarcinoma; Germ cell tumors; Idiopathic thrombocytopenic purpura; Kaposi sarcoma; Letterer-Siwe disease; Various Lymphomas; Melanoma; Mycosis fungoides; Prostate cancer; Testicular cancer |
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ALT_DEFINITION |
The active ingredient in a drug used together with other drugs to treat several types of cancer, including advanced Hodgkin lymphoma and advanced testicular germinal-cell cancers. It is also being studied in the treatment of other types of cancer. Vinblastine comes from the periwinkle plant Vinca rosea Linn. It blocks cell growth by stopping cell division and may kill cancer cells. It is a type of vinca alkaloid and a type of antimitotic agent. |
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CAS_Registry |
865-21-4 |
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CHEBI_ID |
CHEBI:27375 |
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Chemical_Formula |
C46H58N4O9 |
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code |
C930 |
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Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177406 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
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Contributing_Source |
CTRP FDA GDC HemOnc PCDC |
|
DEFINITION |
A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04) |
|
Display_Name |
Vinblastine |
|
FDA_UNII_Code |
5V9KLZ54CY |
|
FULL_SYN |
VINBLASTINE Vinblastine Vincaleucoblastine vinblastine VLB |
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Has_Salt_Form | ||
Has_Target | ||
Is_PCDC_GCT_Authorized_Value_For_Variable | ||
Is_Value_For_GDC_Property | ||
label |
Vinblastine |
|
Legacy Concept Name |
Vinblastine |
|
Maps_To |
Vinblastine |
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NCI_Drug_Dictionary_ID |
42951 |
|
NSC Number |
90636 |
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PDQ_Closed_Trial_Search_ID |
42951 |
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PDQ_Open_Trial_Search_ID |
42951 |
|
Preferred_Name |
Vinblastine |
|
prefixIRI |
Thesaurus:C930 |
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Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0042670 |
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subClassOf |