National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Pentoxifylline

Synonyms

Oxpentifylline

3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione

Pentoxifylline

PTX

Trental

Pentoxyphylline

pentoxifylline

PENTOXIFYLLINE

Definitions

A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (cAMP) in erythrocytes, endothelium, and the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility, and enhances blood flow. In addition, the increased level of cAMP in platelets inhibits platelet aggregation, which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha and interferon-gamma, while it induces Th2-like (T-helper 2) cytokine production, thereby inhibiting Th1-mediated (T-helper 1) inflammatory and autoimmune responses.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C733

ALT_DEFINITION

A drug used to prevent blood clotting and as a treatment that may help decrease weight loss in people with cancer.

CAS_Registry

6493-05-6

Chemical_Formula

C13H18N4O3

code

C733

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (cAMP) in erythrocytes, endothelium, and the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility, and enhances blood flow. In addition, the increased level of cAMP in platelets inhibits platelet aggregation, which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha and interferon-gamma, while it induces Th2-like (T-helper 2) cytokine production, thereby inhibiting Th1-mediated (T-helper 1) inflammatory and autoimmune responses.

Display_Name

Pentoxifylline

FDA_UNII_Code

SD6QCT3TSU

FULL_SYN

Oxpentifylline

3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione

Pentoxifylline

PTX

Trental

Pentoxyphylline

pentoxifylline

PENTOXIFYLLINE

label

Pentoxifylline

Legacy_Concept_Name

Pentoxifylline

NSC_Code

637086

PDQ_Closed_Trial_Search_ID

41432

PDQ_Open_Trial_Search_ID

41432

Preferred_Name

Pentoxifylline

prefixIRI

ncit:C733

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0030899

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C221

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C744

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1327

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https://bioportal.bioontology.org/ontologies/FTDM.owl#pentoxifylline FASTO LOOM
http://purl.jp/bio/4/id/200906055042872488 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/8013 RXNORM LOOM
http://purl.bioontology.org/ontology/CSP/4006-0076 CRISP LOOM
http://purl.bioontology.org/ontology/VANDF/4018468 VANDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041432 PDQ LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010431 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-A7210 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.759.758.824.651.700 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP14918-4 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU035938 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
http://stirdf.jst.go.jp/id/200907035146649783 IOBC LOOM
http://purl.obolibrary.org/obo/dinto_DB00806 DINTO LOOM
http://purl.bioontology.org/ontology/MESH/D010431 MESH LOOM
http://purl.obolibrary.org/obo/DRON_00015511 DRON LOOM
http://purl.bioontology.org/ontology/NDDF/002098 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0030899 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9447 OCHV LOOM
http://purl.bioontology.org/ontology/UATC/C04AD03 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146791 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00806 FTC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387522004 SNOMEDCT LOOM