National Cancer Institute Thesaurus

Last uploaded: July 29, 2019
Preferred Name

Amiodarone

Synonyms

Amiodarone

AMIODARONE

Definitions

An iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62002

CAS_Registry

1951-25-3

CHEBI_ID

CHEBI:2663

Chemical_Formula

C25H29I2NO3

code

C62002

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.

FDA_UNII_Code

N3RQ532IUT

FULL_SYN

Amiodarone

AMIODARONE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C236

label

Amiodarone

Legacy_Concept_Name

Amiodarone_Base

Preferred_Name

Amiodarone

prefixIRI

ncit:C62002

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0002598

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47793

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93038

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