loading...| Preferred Name |
Melphalan |
|
| Synonyms |
L-Sarcolysin L-Sarcolysine Melphalanum Phenylalanine nitrogen mustard Sarcoclorin Alanine Nitrogen Mustard L-Phenylalanine Mustard L-sarcolysin L-Phenylalanine mustard p-di(chloroethyl)amino-L-phenylalanine Phenylalanine Nitrogen Mustard L-Sarcolysin Phenylalanine mustard 4-[bis(2-chloroethyl)amino]-L-phenylalanine Phenylalanine Mustard CB-3025 L-PAM MELPHALAN Melphalan Sarkolysin WR-19813 melphalan |
|
| Definitions |
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C633 |
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| Accepted_Therapeutic_Use_For |
Breast cancer; neuroblastoma; palliative treatment of multiple myeloma and nonresectable epithelial ovarian carcinoma; rhabdomyosarcoma |
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| ALT_DEFINITION |
A drug that is used to treat multiple myeloma and ovarian epithelial cancer and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents. |
|
| CAS_Registry |
148-82-3 |
|
| CHEBI_ID |
CHEBI:28876 |
|
| Chemical_Formula |
C13H18Cl2N2O2 |
|
| code |
C633 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177406 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc PCDC |
|
| DEFINITION |
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. |
|
| Display_Name |
Melphalan |
|
| FDA_UNII_Code |
Q41OR9510P |
|
| FULL_SYN |
L-Sarcolysin L-Sarcolysine Melphalanum Phenylalanine nitrogen mustard Sarcoclorin Alanine Nitrogen Mustard L-Phenylalanine Mustard L-sarcolysin L-Phenylalanine mustard p-di(chloroethyl)amino-L-phenylalanine Phenylalanine Nitrogen Mustard L-Sarcolysin Phenylalanine mustard 4-[bis(2-chloroethyl)amino]-L-phenylalanine Phenylalanine Mustard CB-3025 L-PAM MELPHALAN Melphalan Sarkolysin WR-19813 melphalan |
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| Has_Salt_Form | ||
| Is_PCDC_AML_Authorized_Value_For_Variable | ||
| Is_PCDC_GCT_Authorized_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Melphalan |
|
| Legacy Concept Name |
Melphalan |
|
| Maps_To |
Melphalan |
|
| NCI_Drug_Dictionary_ID |
779085 |
|
| NSC Number |
241286 8806 |
|
| PDQ_Closed_Trial_Search_ID |
779085 |
|
| PDQ_Open_Trial_Search_ID |
779085 |
|
| Preferred_Name |
Melphalan |
|
| prefixIRI |
Thesaurus:C633 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0025241 |
|
| subClassOf |