Preferred Name |
Methyldopa |
|
Synonyms |
3-Hydroxy-alpha-methyl-L-tyrosine L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic Acid Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine Aldomet Amodopa Dopamet METHYLDOPA Methyldopa |
|
Definitions |
A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47616 |
|
CAS_Registry |
41372-08-1 |
|
CHEBI_ID |
CHEBI:61058 |
|
Chemical_Formula |
2C10H13NO4.3H2O |
|
code |
C47616 |
|
Concept_In_Subset | ||
Contributing_Source |
FDA |
|
DEFINITION |
A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure. |
|
FDA_UNII_Code |
56LH93261Y |
|
FULL_SYN |
3-Hydroxy-alpha-methyl-L-tyrosine L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic Acid Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine Aldomet Amodopa Dopamet METHYLDOPA Methyldopa |
|
label |
Methyldopa |
|
Legacy Concept Name |
Methyldopa |
|
NSC Number |
169916 |
|
Preferred_Name |
Methyldopa |
|
prefixIRI |
Thesaurus:C47616 |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0025741 |
|
subClassOf |