Medical Subject Headings

Last uploaded: July 6, 2018
Preferred Name

Amyotrophic Lateral Sclerosis

Synonyms

ALS (Amyotrophic Lateral Sclerosis)

Definitions

A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

ID

http://purl.bioontology.org/ontology/MESH/D000690

altLabel

ALS (Amyotrophic Lateral Sclerosis)

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Sclerosis, Amyotrophic Lateral

Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1

Lou-Gehrigs Disease

Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam

Guam Disease

Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1

Charcot Disease

Lou Gehrig's Disease

Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam

Disease, Lou-Gehrigs

Guam Form of Amyotrophic Lateral Sclerosis

Disease, Guam

Gehrig Disease

Lou Gehrig Disease

Gehrig's Disease

Gehrigs Disease

Amyotrophic Lateral Sclerosis, Guam Form

AQL

BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI

cui

C0393554

C0543859

C0002736

DC

1

definition

A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

DX

19660101

Inverse of AQ

http://purl.bioontology.org/ontology/MESH/Q000401

http://purl.bioontology.org/ontology/MESH/Q000150

http://purl.bioontology.org/ontology/MESH/Q000188

http://purl.bioontology.org/ontology/MESH/Q000517

http://purl.bioontology.org/ontology/MESH/Q000201

http://purl.bioontology.org/ontology/MESH/Q000145

http://purl.bioontology.org/ontology/MESH/Q000503

http://purl.bioontology.org/ontology/MESH/Q000453

http://purl.bioontology.org/ontology/MESH/Q000208

http://purl.bioontology.org/ontology/MESH/Q000134

http://purl.bioontology.org/ontology/MESH/Q000821

http://purl.bioontology.org/ontology/MESH/Q000382

http://purl.bioontology.org/ontology/MESH/Q000601

http://purl.bioontology.org/ontology/MESH/Q000235

http://purl.bioontology.org/ontology/MESH/Q000523

http://purl.bioontology.org/ontology/MESH/Q000276

http://purl.bioontology.org/ontology/MESH/Q000191

http://purl.bioontology.org/ontology/MESH/Q000652

http://purl.bioontology.org/ontology/MESH/Q000662

http://purl.bioontology.org/ontology/MESH/Q000151

http://purl.bioontology.org/ontology/MESH/Q000628

http://purl.bioontology.org/ontology/MESH/Q000196

http://purl.bioontology.org/ontology/MESH/Q000534

http://purl.bioontology.org/ontology/MESH/Q000266

http://purl.bioontology.org/ontology/MESH/Q000532

http://purl.bioontology.org/ontology/MESH/Q000139

http://purl.bioontology.org/ontology/MESH/Q000378

http://purl.bioontology.org/ontology/MESH/Q000175

http://purl.bioontology.org/ontology/MESH/Q000000981

http://purl.bioontology.org/ontology/MESH/Q000097

http://purl.bioontology.org/ontology/MESH/Q000473

http://purl.bioontology.org/ontology/MESH/Q000451

http://purl.bioontology.org/ontology/MESH/Q000209

http://purl.bioontology.org/ontology/MESH/Q000178

http://purl.bioontology.org/ontology/MESH/Q000469

Inverse of SIB

http://purl.bioontology.org/ontology/MESH/D009134

http://purl.bioontology.org/ontology/MESH/D020758

http://purl.bioontology.org/ontology/MESH/D052879

http://purl.bioontology.org/ontology/MESH/D016750

http://purl.bioontology.org/ontology/MESH/D013119

http://purl.bioontology.org/ontology/MESH/D010244

http://purl.bioontology.org/ontology/MESH/D063205

http://purl.bioontology.org/ontology/MESH/D009187

http://purl.bioontology.org/ontology/MESH/D057174

http://purl.bioontology.org/ontology/MESH/D020802

http://purl.bioontology.org/ontology/MESH/D013595

http://purl.bioontology.org/ontology/MESH/D013132

http://purl.bioontology.org/ontology/MESH/D013120

http://purl.bioontology.org/ontology/MESH/D013606

http://purl.bioontology.org/ontology/MESH/D013117

Mapped from

http://purl.bioontology.org/ontology/MESH/C538251

http://purl.bioontology.org/ontology/MESH/C565956

http://purl.bioontology.org/ontology/MESH/C563895

http://purl.bioontology.org/ontology/MESH/C531617

http://purl.bioontology.org/ontology/MESH/C567244

http://purl.bioontology.org/ontology/MESH/C567699

http://purl.bioontology.org/ontology/MESH/C567499

http://purl.bioontology.org/ontology/MESH/C563708

http://purl.bioontology.org/ontology/MESH/C565955

http://purl.bioontology.org/ontology/MESH/C566290

http://purl.bioontology.org/ontology/MESH/C566288

http://purl.bioontology.org/ontology/MESH/C566576

http://purl.bioontology.org/ontology/MESH/C564688

http://purl.bioontology.org/ontology/MESH/C565957

http://purl.bioontology.org/ontology/MESH/C567429

http://purl.bioontology.org/ontology/MESH/C564300

http://purl.bioontology.org/ontology/MESH/C566550

MDA

19990101

MMR

20130708

MN

C10.574.950.050

C10.668.467.250

C10.228.854.139

C18.452.845.800.050

C10.574.562.250

notation

D000690

prefLabel

Amyotrophic Lateral Sclerosis

TERMUI

T814256

T782950

T366068

T845605

T366066

T002090

T366065

T002092

T366064

T366063

T002091

T366069

T840894

T753625

T366067

TH

NLM (2013)

NLM (1990)

NLM (2000)

NLM (1966)

NLM (2010)

NLM (2014)

BIOETHICS (1998)

NLM (2012)

ORD (2010)

GHR (2014)

tui

T047

subClassOf

http://purl.bioontology.org/ontology/MESH/D013118

http://purl.bioontology.org/ontology/MESH/D016472

http://purl.bioontology.org/ontology/MESH/D057177

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http://purl.bioontology.org/ontology/MEDDRA/10052889 Medical Dictionary for Regulatory Activities CUI
http://purl.bioontology.org/ontology/NDFRT/N0000000376 National Drug File - Reference Terminology CUI
http://purl.bioontology.org/ontology/MDRFRE/10002026 MDRFRE CUI
http://purl.bioontology.org/ontology/SNMI/DA-23010 Systematized Nomenclature of Medicine, International Version CUI
http://purl.bioontology.org/ontology/SNMI/DA-23010 Systematized Nomenclature of Medicine, International Version LOOM
http://purl.bioontology.org/ontology/MSHFRE/D000690 Thesaurus Biomedical Francais/Anglais [French translation of MeSH] CUI
http://purl.bioontology.org/ontology/MSHFRE/D000690 Thesaurus Biomedical Francais/Anglais [French translation of MeSH] CUI
http://purl.bioontology.org/ontology/MSHFRE/D000690 Thesaurus Biomedical Francais/Anglais [French translation of MeSH] CUI
http://dbpedia.org/resource/Amyotrophic_lateral_sclerosis Dispedia Core Ontology LOOM
http://purl.obolibrary.org/obo/ND_0000120 Neurodegenerative Disease Data Ontology LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D000690 Robert Hoehndorf Version of MeSH LOOM
http://www.limics.org/hrdo/rdfns#pat_id_106 Disease core ontology applied to Rare Diseases LOOM
http://purl.bioontology.org/ontology/SCTSPA/230258005 SNOMED Terminos Clinicos CUI
http://purl.bioontology.org/ontology/RCD/X002m Read Codes, Clinical Terms Version 3 (CTV3) CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C18.452.845.800.050 Robert Hoehndorf Version of MeSH LOOM
http://www.orpha.net/ORDO/Orphanet_803 Orphanet Rare Disease Ontology LOOM
http://www.orpha.net/ORDO/Orphanet_803 Holistic Ontology of Rare Diseases LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/86044005 SNOMED CT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/86044005 SNOMED CT LOOM
http://www.gamuts.net/entity#amyotrophic_lateral_sclerosis Radiology Gamuts Ontology LOOM
http://purl.bioontology.org/ontology/ICD9CM/335.20 International Classification of Diseases, Version 9 - Clinical Modification CUI
http://purl.bioontology.org/ontology/ICD9CM/335.20 International Classification of Diseases, Version 9 - Clinical Modification LOOM
http://purl.bioontology.org/ontology/MEDDRA/10002026 Medical Dictionary for Regulatory Activities CUI
http://purl.bioontology.org/ontology/MEDDRA/10002026 Medical Dictionary for Regulatory Activities LOOM
http://purl.bioontology.org/ontology/CSP/4000-0117 Computer Retrieval of Information on Scientific Projects Thesaurus CUI
http://purl.bioontology.org/ontology/CSP/4000-0117 Computer Retrieval of Information on Scientific Projects Thesaurus LOOM
http://uri.neuinfo.org/nif/nifstd/birnlex_12566 Neuroscience Information Framework (NIF) Dysfunction Ontlogy LOOM
http://uri.neuinfo.org/nif/nifstd/birnlex_12566 Neuroscience Information Framework (NIF) Standard Ontology LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C10.668.467.250 Robert Hoehndorf Version of MeSH LOOM
http://purl.obolibrary.org/obo/DOID_332 BioAssay Ontology LOOM
http://purl.obolibrary.org/obo/DOID_332 Drug Target Ontology LOOM
http://purl.obolibrary.org/obo/DOID_332 Human Disease Ontology LOOM
http://purl.obolibrary.org/obo/DOID_332 Neuroscience Information Framework (NIF) Standard Ontology LOOM
http://doe-generated-ontology.com/OntoAD#C0002736 Bilingual Ontology of Alzheimer's Disease and Related Diseases LOOM
http://purl.bioontology.org/ontology/MDRFRE/10052889 MDRFRE CUI
http://localhost/plosthes.2017-1#4054 PLOS Thesaurus LOOM
http://www.owl-ontologies.com/NPOntology.owl#DOID_332 Natural Products Ontology LOOM
http://www.radlex.org/RID/#RID5128 Radiology Lexicon LOOM
http://scai.fraunhofer.de/AlzheimerOntology#Amyotrophic_lateral_sclerosis Alzheimer's disease ontology LOOM
http://purl.jp/bio/4/id/200906049502955239 Interlinking Ontology for Biological Concepts LOOM
http://purl.obolibrary.org/obo/HP_0007354 Children's Health Exposure Analysis Resource LOOM
http://purl.obolibrary.org/obo/HP_0007354 Combined Phenotype Ontology LOOM
http://purl.obolibrary.org/obo/HP_0007354 Human Phenotype Ontology LOOM
http://purl.obolibrary.org/obo/HP_0007354 Monarch Disease Ontology LOOM
http://identifiers.org/omim/105400 Gene Expression Ontology LOOM
http://identifiers.org/omim/105400 Regulation of Gene Expression Ontolology LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/230258005 SNOMED CT CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C10.228.854.139 Robert Hoehndorf Version of MeSH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C10.574.950.050 Robert Hoehndorf Version of MeSH LOOM
http://purl.bioontology.org/ontology/RCTV2/F152000 Read Clinical Terminology Version 2 LOOM
http://purl.bioontology.org/ontology/ICD10CM/G12.21 International Classification of Diseases, Version 10 - Clinical Modification CUI
http://purl.bioontology.org/ontology/ICD10CM/G12.21 International Classification of Diseases, Version 10 - Clinical Modification LOOM
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0002736 MedlinePlus Health Topics CUI
http://purl.bioontology.org/ontology/OMIM/105500 Online Mendelian Inheritance in Man CUI
http://purl.bioontology.org/ontology/OMIM/MTHU038375 Online Mendelian Inheritance in Man CUI
http://purl.bioontology.org/ontology/OMIM/MTHU038375 Online Mendelian Inheritance in Man LOOM
http://purl.bioontology.org/ontology/SCTSPA/86044005 SNOMED Terminos Clinicos CUI
http://www.ebi.ac.uk/efo/EFO_0000253 Cell Culture Ontology LOOM
http://www.ebi.ac.uk/efo/EFO_0000253 Experimental Factor Ontology LOOM
http://www.ebi.ac.uk/efo/EFO_0000253 Cell Line Ontology LOOM
http://www.ebi.ac.uk/efo/EFO_0000253 Experimental Factor Ontology LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Amyotrophic_Lateral_Sclerosis APA Neuro Cluster LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Amyotrophic_Lateral_Sclerosis Psychology Ontology LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Amyotrophic_Lateral_Sclerosis Cigarette Smoke Exposure Ontology LOOM
http://purl.obolibrary.org/obo/OMIM_105400 Regulation of Transcription Ontology LOOM
http://purl.bioontology.org/ontology/OMIM/MTHU030638 Online Mendelian Inheritance in Man CUI
http://purl.obolibrary.org/obo/MONDO_0004976 Monarch Disease Ontology LOOM
http://purl.bioontology.org/ontology/LNC/LA27534-9 Logical Observation Identifier Names and Codes CUI
http://purl.bioontology.org/ontology/LNC/LA27534-9 Logical Observation Identifier Names and Codes LOOM
http://purl.bioontology.org/ontology/RCD/F152. Read Codes, Clinical Terms Version 3 (CTV3) CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C10.574.562.250 Robert Hoehndorf Version of MeSH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34373 National Cancer Institute Thesaurus LOOM
http://www.semanticweb.org/ontologies/2012/0/Ontology1325521724189.owl#Amyotrophic_Lateral_Scherosis Clinical Trials Ontology LOOM
http://www.limics.fr/ontologies/ontolurgences#ScleroseLateraleAmyotrophique Emergency care ontology LOOM
http://www.limics.fr/ontologies/ontoparonmed#ScleroseLateraleAmyotrophique Ontology of Amyotrophic Lateral Sclerosis, all modules LOOM
http://bioontology.org/projects/ontologies/birnlex#birnlex_12566 Biomedical Informatics Research Network Project Lexicon LOOM
http://id.loc.gov/authorities/subjects/sh85004728 FAST (Faceted Application of Subject Terminology) Topical Facet LOOM