The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	colchicine
Synonyms	N-{3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^{2,7}]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl}acetamide C22H25NO6
ID	http://purl.obolibrary.org/obo/dinto_DB01394
AHFScode	92:02.00* 92:00.00
ATCCode	M04AC01
CASRN	64-86-8
DBBrand	colcrys
DBSynonym	colchicin colchicinum colchicina
Definition	A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (periodic disease). [PubChem]
has effect	http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000882 http://purl.obolibrary.org/obo/OAE_0001286 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0001378 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000525 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000344 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000242 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0915 http://purl.obolibrary.org/obo/dinto_2701
InChI	InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)
InChIKey	InChIKey=IAKHMKGGTNLKSZ-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_1988 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1221
inhibits	http://purl.obolibrary.org/obo/dinto_1972 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0915 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_2701 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465
is metabolised by	http://purl.obolibrary.org/obo/dinto_0901
is transported by	http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_2828
label	colchicine
may interact with	http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_38545 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/CHEBI_9150 http://purl.obolibrary.org/obo/CHEBI_40303 http://purl.obolibrary.org/obo/CHEBI_3558 http://purl.obolibrary.org/obo/CHEBI_3764 http://purl.obolibrary.org/obo/CHEBI_681850 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB01361 http://purl.obolibrary.org/obo/CHEBI_32020 http://purl.obolibrary.org/obo/CHEBI_5136 http://purl.obolibrary.org/obo/CHEBI_39548 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/CHEBI_3090 http://purl.obolibrary.org/obo/CHEBI_8361 http://purl.obolibrary.org/obo/dinto_DB00976
prefixIRI	obo2:dinto_DB01394
prefLabel	colchicine
SMILES	COC1=CC2=C(C(OC)=C1OC)C1=CC=C(OC)C(=O)C=C1C(CC2)NC(C)=O
Synonym	N-{3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^{2,7}]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl}acetamide C22H25NO6
xref	RxList:http://www.rxlist.com/cgi/generic/colch.htm PharmGKB:PA449092 PDB:LOC National Drug Code Directory:13310-119-07 Drugs Product Database (DPD):396 IUPHAR:2367 ChEBI:23359 Drugs.com:http://www.drugs.com/cdi/colchicine.html Wikipedia:http://en.wikipedia.org/wiki/Colchicine Guide To Pharmacology:2367
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/FBcv_0000577	FB-CV	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	FB-CV	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	CHEBI	LOOM
http://purl.obolibrary.org/obo/OMIT_0004388	OMIT	LOOM
http://purl.bioontology.org/ontology/VANDF/4017416	VANDF	LOOM
http://purl.jp/bio/4/id/200906082457562538	IOBC	LOOM
http://purl.bioontology.org/ontology/SNMI/C-60170	SNMI	LOOM
http://www.drugbank.ca/drugs/DB01394	FTC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3142	OCHV	LOOM
http://purl.obolibrary.org/obo/MESH_D003078	BERO	LOOM
http://purl.bioontology.org/ontology/ATC/M04AC01	ATC	LOOM
http://purl.bioontology.org/ontology/CSP/0092-0146	CRISP	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387413002	SNOMEDCT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000145804	ODAE	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003078	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0009262	OCHV	LOOM
http://purl.bioontology.org/ontology/LNC/LP18089-0	LOINC	LOOM
http://purl.bioontology.org/ontology/RCD/j62..	RCD	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003371	LOINC	LOOM
http://www.co-ode.org/ontologies/galen#Colchicine	GALEN	LOOM
http://www.gamuts.net/entity#colchicine	GAMUTS	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C385	NCIT	LOOM
http://purl.obolibrary.org/obo/FBcv_0000577	FB-CV	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	FB-CV	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	UPHENO	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	PECO	LOOM
http://purl.obolibrary.org/obo/CHEBI_23359	ODNAE	LOOM
https://go.drugbank.com/drugs/DB01394	MDM	LOOM
http://stirdf.jst.go.jp/id/200907075810136871	IOBC	LOOM
http://purl.bioontology.org/ontology/MESH/D003078	MESH	LOOM
http://purl.bioontology.org/ontology/NDDF/002372	NDDF	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039188	PDQ	LOOM
http://purl.obolibrary.org/obo/EO_0007526	PEAO	LOOM
http://purl.obolibrary.org/obo/NCIT_C385	BERO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018118	PMAPP-PMO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.225	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/2683	RXNORM	LOOM
http://localhost/plosthes.2017-1#9800	PLOSTHES	LOOM