loading...| Preferred Name |
ethambutol |
|
| Synonyms |
(2S)-2-[(2-{[(2S)-1-hydroxybutan-2-yl]amino}ethyl)amino]butan-1-ol S,S-Ethambutol etambutol (+)-S,S-ethambutol (+)-ethambutol EMB C10H24N2O2 (2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol ethambutol ethambutolum (S,S)-ethambutol Ethambutol (+)-2,2'-(ethylenediimino)di-1-butanol (2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol (+)-N,N'-bis(1-(hydroxymethyl)propyl)ethylenediamine |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_4877 |
|
| AHFScode |
08:16.04 |
|
| altId |
CHEBI:133410 CHEBI:659237 CHEBI:678172 |
|
| ATCCode |
J04AK02 |
|
| CASRN |
74-55-5 |
|
| DBBrand |
tibutol diambutol dadibutol myambutol etibi |
|
| DBname |
ethambutol |
|
| DBSynonym |
ethambutol dihydrochloride ethambutol hydrochloride aethambutolum ethambutol, racemic mixture etambutolo [dcit] ethambutolum [inn-latin] ethambutol hcl etambutol [inn-spanish] d-ethambutol emb |
|
| Definition |
Ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone. |
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001510 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000577 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000341 http://purl.obolibrary.org/obo/OAE_0001145 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000881 |
|
| has pharmacological target |
http://purl.obolibrary.org/obo/dinto_2818 |
|
| has role | ||
| InChI |
InChI=1S/C10H24N2O2/c1-3-9(7-13)11-5-6-12-10(4-2)8-14/h9-14H,3-8H2,1-2H3/t9-,10-/m0/s1 |
|
| InChIKey |
InChIKey=AEUTYOVWOVBAKS-UWVGGRQHSA-N |
|
| inhibits |
http://purl.obolibrary.org/obo/dinto_2818 |
|
| label |
ethambutol |
|
| prefixIRI |
obo2:CHEBI_4877 |
|
| prefLabel |
ethambutol |
|
| SMILES |
CC[C@@H](CO)NCCN[C@@H](CC)CO |
|
| Synonym |
(2S)-2-[(2-{[(2S)-1-hydroxybutan-2-yl]amino}ethyl)amino]butan-1-ol S,S-Ethambutol etambutol (+)-S,S-ethambutol (+)-ethambutol EMB C10H24N2O2 (2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol ethambutol ethambutolum (S,S)-ethambutol Ethambutol (+)-2,2'-(ethylenediimino)di-1-butanol (2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol (+)-N,N'-bis(1-(hydroxymethyl)propyl)ethylenediamine |
|
| xref |
ChEMBL:17562368 Wikipedia:http://en.wikipedia.org/wiki/Ethambutol ChEBI:4877 Drugs Product Database (DPD):247960 ChEMBL:19648006 ChEMBL:10891117 Beilstein:6312870 ChEMBL:14695841 Drugs.com:http://www.drugs.com/cdi/ethambutol.html CASRN:74-55-5 ChEMBL:16005211 National Drug Code Directory:0555-0923-02 ChEMBL:3934384 ChEMBL:17276683 ChEMBL:17210775 ChEMBL:167617 ChEMBL:17239593 RxList:http://www.rxlist.com/cgi/generic2/ethambutol.htm ChEMBL:17331717 ChEMBL:12182855 BindingDB:50204422 ChEMBL:15225698 DrugBank:DB00330 ChEMBL:10649975 ChEMBL:17315960 ChEMBL:10966749 KEGG DRUG:D07925 KEGG COMPOUND:C06984 ChEMBL:19524332 Wikipedia:Ethambutol ChEMBL:16870429 ChEMBL:17851083 PharmGKB:PA164784021 ChEMBL:16759086 ChEMBL:17888665 ChEMBL:14698152 |
|
| subClassOf |