loading...| Preferred Name |
Glioblastoma |
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| Synonyms |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Glioblastoma |
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| DEFINITION |
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma). Two histologic variants are recognized: giant cell glioblastoma and gliosarcoma. (WHO) |
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| FULL_SYN |
GBM (Glioblastoma) Glioblastoma Multiforme GBM Grade IV Astrocytic Neoplasm Grade IV Astrocytic Tumor Spongioblastoma Multiforme grade IV astrocytoma |
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| isDefinedBy |
The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma). Two histologic variants are recognized: giant cell glioblastoma and gliosarcoma. (WHO) |
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| label |
Glioblastoma |
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| prefixIRI |
Thesaurus:Glioblastoma |
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| prefLabel |
Glioblastoma |
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| Synonym |
GBM (Glioblastoma) Glioblastoma Multiforme GBM Grade IV Astrocytic Neoplasm Grade IV Astrocytic Tumor Spongioblastoma Multiforme grade IV astrocytoma |
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| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Astrocytic_Tumor http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Malignant_Glioma http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Anaplastic_Malignant_Neoplasm |