loading...| Preferred Name |
microglial cell |
|
| Synonyms |
hortega cells microgliocyte brain-resident macrophage brain macrophage MF.microglia.CNS microglia |
|
| Definitions |
Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. |
|
| ID |
http://purl.obolibrary.org/obo/CL_0000129 |
|
| comment |
Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. |
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| ccf_ct_isa | ||
| ccf_located_in |
http://purl.obolibrary.org/obo/UBERON_0000966 http://purl.obolibrary.org/obo/UBERON_0001384 http://purl.obolibrary.org/obo/UBERON_0000970 http://purl.obolibrary.org/obo/UBERON_0001890 http://purl.obolibrary.org/obo/UBERON_0002792 http://purl.obolibrary.org/obo/UBERON_0026386 http://purl.obolibrary.org/obo/UBERON_0019264 http://purl.obolibrary.org/obo/UBERON_0031906 http://purl.obolibrary.org/obo/UBERON_0016525 http://purl.obolibrary.org/obo/UBERON_0030276 http://purl.obolibrary.org/obo/UBERON_0014638 http://purl.obolibrary.org/obo/UBERON_0001870 http://purl.obolibrary.org/obo/UBERON_0029636 http://purl.obolibrary.org/obo/UBERON_0002240 |
|
| ccf_pref_label |
microglial cell microglia |
|
| database_cross_reference |
BTO:0000078 BTO:0000962 FMA:54539 FMA:54540 |
|
| definition |
A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. |
|
| has exact synonym |
hortega cells microgliocyte brain-resident macrophage |
|
| has_broad_synonym |
brain macrophage |
|
| has_related_synonym |
MF.microglia.CNS microglia |
|
| id |
CL:0000129 |
|
| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas |
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| isDefinedBy | ||
| label |
microglial cell |
|
| notation |
CL:0000129 |
|
| prefLabel |
microglial cell Microglia microglia |
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| present_in_taxon | ||
| subClassOf |