loading...| Preferred Name |
Nicotine |
|
| Synonyms |
|
|
| Definitions |
A plant alkaloid, found in the tobacco plant, and addictive central nervous system (CNS) stimulant that causes either ganglionic stimulation in low doses or ganglionic blockage in high doses. Nicotine acts as an agonist at the nicotinic cholinergic receptors in the autonomic ganglia, at neuromuscular junctions, and in the adrenal medulla and the brain. Nicotine's CNS-stimulating activities may be mediated through the release of several neurotransmitters, including acetylcholine, beta-endorphin, dopamine, norepinephrine, serotonin, and ACTH. As a result, peripheral vasoconstriction, tachycardia, and elevated blood pressure may be observed with nicotine intake. This agent may also stimulate the chemoreceptor trigger zone, thereby inducing nausea and vomiting. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C691 |
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| Accepted_Therapeutic_Use_For |
Smoking Cessation |
|
| ALT_DEFINITION |
An addictive, poisonous chemical found in tobacco. It can also be made in the laboratory. When it enters the body, nicotine causes an increased heart rate and use of oxygen by the heart, and a sense of well-being and relaxation. It is also used as an insecticide. |
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| CAS_Registry |
54-11-5 |
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| CHEBI_ID |
CHEBI:17688 |
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| Chemical_Formula |
C10H14N2 |
|
| code |
C691 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A plant alkaloid, found in the tobacco plant, and addictive central nervous system (CNS) stimulant that causes either ganglionic stimulation in low doses or ganglionic blockage in high doses. Nicotine acts as an agonist at the nicotinic cholinergic receptors in the autonomic ganglia, at neuromuscular junctions, and in the adrenal medulla and the brain. Nicotine's CNS-stimulating activities may be mediated through the release of several neurotransmitters, including acetylcholine, beta-endorphin, dopamine, norepinephrine, serotonin, and ACTH. As a result, peripheral vasoconstriction, tachycardia, and elevated blood pressure may be observed with nicotine intake. This agent may also stimulate the chemoreceptor trigger zone, thereby inducing nausea and vomiting. |
|
| Display_Name |
Nicotine |
|
| FDA_UNII_Code |
6M3C89ZY6R |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 |
|
| label |
Nicotine |
|
| Legacy Concept Name |
Nicotine |
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| NCI_Drug_Dictionary_ID |
42243 |
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| NSC Number |
5065 |
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| PDQ_Closed_Trial_Search_ID |
42243 |
|
| PDQ_Open_Trial_Search_ID |
42243 |
|
| Preferred_Name |
Nicotine |
|
| prefixIRI |
NCIT:C691 |
|
| prefLabel |
Nicotine |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0028040 |
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| subClassOf |