loading...| Preferred Name |
Melphalan |
|
| Synonyms |
|
|
| Definitions |
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C633 |
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| Accepted_Therapeutic_Use_For |
Breast cancer; neuroblastoma; palliative treatment of multiple myeloma and nonresectable epithelial ovarian carcinoma; rhabdomyosarcoma |
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| ALT_DEFINITION |
A drug that is used to treat multiple myeloma and ovarian epithelial cancer and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents. |
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| CAS_Registry |
148-82-3 |
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| CHEBI_ID |
CHEBI:28876 |
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| Chemical_Formula |
C13H18Cl2N2O2 |
|
| code |
C633 |
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| Contributing_Source |
CTRP FDA PCDC |
|
| definition |
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. |
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| Display_Name |
Melphalan |
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| FDA_UNII_Code |
Q41OR9510P |
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C174019 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C177406 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 |
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| Is_PCDC_AML_Permissible_Value_For_Variable | ||
| Is_PCDC_GCT_Permissible_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Melphalan |
|
| Legacy Concept Name |
Melphalan |
|
| Maps_To |
Melphalan |
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| NCI_Drug_Dictionary_ID |
779085 |
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| NSC Number |
241286 8806 |
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| PDQ_Closed_Trial_Search_ID |
779085 |
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| PDQ_Open_Trial_Search_ID |
779085 |
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| Preferred_Name |
Melphalan |
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| prefixIRI |
NCIT:C633 |
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| prefLabel |
Melphalan |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C0025241 |
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| subClassOf |