Preferred Name |
Ethambutol |
|
Synonyms |
|
|
Definitions |
An antibiotic with bacteriostatic, antimicrobial and antitubercular properties. Ethambutol interferes with the biosynthesis of arabinogalactan, a major polysaccharide of the mycobacterial cell wall. It inhibits the polymerization of cell wall arabinan of arabinogalactan and lipoarabinomannan by blocking arabinosyl transferases and induces the accumulation of D-arabinofuranosyl-P-decaprenol, an intermediate in arabinan biosynthesis. This results in halting bacterial growth. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C61755 |
|
CAS_Registry |
74-55-5 |
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CHEBI_ID |
CHEBI:4877 |
|
Chemical_Formula |
C10H24N2O2 |
|
code |
C61755 |
|
Contributing_Source |
FDA |
|
definition |
An antibiotic with bacteriostatic, antimicrobial and antitubercular properties. Ethambutol interferes with the biosynthesis of arabinogalactan, a major polysaccharide of the mycobacterial cell wall. It inhibits the polymerization of cell wall arabinan of arabinogalactan and lipoarabinomannan by blocking arabinosyl transferases and induces the accumulation of D-arabinofuranosyl-P-decaprenol, an intermediate in arabinan biosynthesis. This results in halting bacterial growth. |
|
FDA_UNII_Code |
8G167061QZ |
|
Has_Salt_Form | ||
in_subset | ||
label |
Ethambutol |
|
Legacy Concept Name |
Ethambutol |
|
NCI_Drug_Dictionary_ID |
701810 |
|
PDQ_Closed_Trial_Search_ID |
701810 |
|
PDQ_Open_Trial_Search_ID |
701810 |
|
Preferred_Name |
Ethambutol |
|
prefixIRI |
NCIT:C61755 |
|
prefLabel |
Ethambutol |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0014964 |
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subClassOf |