loading...| Preferred Name |
Cyclophosphamide |
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| Synonyms |
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|
| Definitions |
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C405 |
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| Accepted_Therapeutic_Use_For |
Breast cancer; Leukemias; Lupus nephritis; Lymphoma; Multiple myeloma; Neuroblastoma; Nephrotic syndrome; Ovarian cancer; Retinoblastoma; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia |
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| ALT_DEFINITION |
A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It is also used to treat some types of kidney disease in children. Cyclophosphamide attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent. |
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| CAS_Registry |
6055-19-2 |
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| CHEBI_ID |
CHEBI:4026 |
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| Chemical_Formula |
C7H15Cl2N2O2P.H2O |
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| code |
C405 |
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| Contributing_Source |
CTRP FDA GDC PCDC |
|
| definition |
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. |
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| Display_Name |
Cyclophosphamide |
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| FDA_UNII_Code |
8N3DW7272P |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C174019 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C177406 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 |
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| Is_PCDC_AML_Permissible_Value_For_Variable | ||
| Is_PCDC_GCT_Permissible_Value_For_Variable | ||
| Is_Value_For_GDC_Property | ||
| label |
Cyclophosphamide |
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| Legacy Concept Name |
Cyclophosphamide |
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| Maps_To |
Cyclophosphamide |
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| NCI_Drug_Dictionary_ID |
39748 |
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| NSC Number |
26271 |
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| PDQ_Closed_Trial_Search_ID |
39748 |
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| PDQ_Open_Trial_Search_ID |
39748 |
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| Preferred_Name |
Cyclophosphamide |
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| prefixIRI |
NCIT:C405 |
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| prefLabel |
Cyclophosphamide |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0010583 |
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| subClassOf |